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Premalignant Gastri...
Premalignant Gastric Lesions in Patients Included in National Colorectal Cancer Screening
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2017-12-07
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Walter de Gruyter GmbH,2018
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:137770840
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http://kipublications.ki.se/Default.aspx?queryparsed=id:137770840URI
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https://doi.org/10.1515/raon-2017-0054DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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BackgroundGastric cancer is the fifth most common malignancy in the world with almost one million new cases annually. Helicobacter pylori infection causes 89% of all gastric cancers. Premalignant lesions (atrophy and intestinal metaplasia) develop after several decades of inflammation. Secondary prevention with gastroscopy is possible, but it is costly and has a low compliance rate. Alternative procedures like serology testing for pepsinogen I and II and pepsinogen I/II ratio are available to select patients for surveillance gastroscopies.Patients and methodsIn seven outpatient endoscopic units, 288 patients (154 men; 53.5%), average age 60.68 years, tested positive in National colorectal cancer screening programme SVIT, were included in the study. Gastropanel (BioHit, Finland) was used as a serologic biopsy method.ResultsWe found 24 patients (12 men, mean age 63.7 years) with pepsinogen (pepsinogen I/II < 3 and/or pepsinogen I < 30 μg/L). Premalignant changes were found on gastric biopsies in 21 patients (7.3% incidence). Operative Link on Gastric Intestinal Metaplasia Assessment (OLGIM) ≥ 1 was found in 20 patients; Operative Link for Gastritis Assessment (OLGA) ≥ 1 was found in 19 patients. Combined accuracy for preneoplastic lesions in Gastropanel positive patients was 87.5%. H. pylori seropositivity was found in 219 patients (76%). Only 24% of our population had normal results.ConclusionsGastropanel test has proven to be a reliable non-invasive test for advanced gastric preneoplastic lesions that can select patients for further gastroscopy. We found high H. pylori seropositivity in older age groups in Slovenia.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Seruga, M
(författare)
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Vujasinovic, MKarolinska Institutet
(författare)
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Urlep, D
(författare)
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Ljepovic, L
(författare)
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Brglez, JN
(författare)
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Forte, A
(författare)
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Kek, LA
(författare)
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Skvarc, M
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Radiology and oncology: Walter de Gruyter GmbH52:1, s. 7-131318-20991581-3207
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