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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Soler Artigas, María (author)
Wain, Louise V (author)
Miller, Suzanne (author)
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Kheirallah, Abdul Kader (author)
Huffman, Jennifer E (author)
Ntalla, Ioanna (author)
Shrine, Nick (author)
Obeidat, Ma'en (author)
Trochet, Holly (author)
McArdle, Wendy L (author)
Alves, Alexessander Couto (author)
Hui, Jennie (author)
Zhao, Jing Hua (author)
Joshi, Peter K (author)
Teumer, Alexander (author)
Albrecht, Eva (author)
Imboden, Medea (author)
Rawal, Rajesh (author)
Lopez, Lorna M (author)
Marten, Jonathan (author)
Enroth, Stefan (author)
Surakka, Ida (author)
Polasek, Ozren (author)
Lyytikäinen, Leo-Pekka (author)
Granell, Raquel (author)
Hysi, Pirro G (author)
Flexeder, Claudia (author)
Mahajan, Anubha (author)
Beilby, John (author)
Bossé, Yohan (author)
Brandsma, Corry-Anke (author)
Campbell, Harry (author)
Gieger, Christian (author)
Gläser, Sven (author)
González, Juan R (author)
Grallert, Harald (author)
Hammond, Chris J (author)
Harris, Sarah E (author)
Hartikainen, Anna-Liisa (author)
Heliövaara, Markku (author)
Henderson, John (author)
Hocking, Lynne (author)
Horikoshi, Momoko (author)
Hutri-Kähönen, Nina (author)
Ingelsson, Erik (author)
Johansson, Åsa (author)
Kemp, John P (author)
Kolcic, Ivana (author)
Kumar, Ashish (author)
Lind, Lars (author)
Melén, Erik (author)
Musk, Arthur W (author)
Navarro, Pau (author)
Nickle, David C (author)
Padmanabhan, Sandosh (author)
Raitakari, Olli T (author)
Ried, Janina S (author)
Ripatti, Samuli (author)
Schulz, Holger (author)
Scott, Robert A (author)
Sin, Don D (author)
Starr, John M (author)
Viñuela, Ana (author)
Völzke, Henry (author)
Wild, Sarah H (author)
Wright, Alan F (author)
Zemunik, Tatijana (author)
Jarvis, Deborah L (author)
Spector, Tim D (author)
Evans, David M (author)
Lehtimäki, Terho (author)
Vitart, Veronique (author)
Kähönen, Mika (author)
Gyllensten, Ulf (author)
Rudan, Igor (author)
Deary, Ian J (author)
Karrasch, Stefan (author)
Probst-Hensch, Nicole M (author)
Heinrich, Joachim (author)
Stubbe, Beate (author)
Wilson, James F (author)
Wareham, Nicholas J (author)
James, Alan L (author)
Morris, Andrew P (author)
Jarvelin, Marjo-Riitta (author)
Hayward, Caroline (author)
Sayers, Ian (author)
Strachan, David P (author)
Hall, Ian P (author)
Tobin, Martin D (author)
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2015
2015
English.
In: Nature Communications. - 2041-1723. ; 6
  • swepub:Mat__t
Abstract Subject headings
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  • Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

Subject headings

Natural Sciences  (hsv)
Biological Sciences  (hsv)
Genetics  (hsv)
Naturvetenskap  (hsv)
Biologiska vetenskaper  (hsv)
Genetik  (hsv)

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Soler Artigas, M ...
Wain, Louise V
Miller, Suzanne
Kheirallah, Abdu ...
Huffman, Jennife ...
Ntalla, Ioanna
show more...
Shrine, Nick
Obeidat, Ma'en
Trochet, Holly
McArdle, Wendy L
Alves, Alexessan ...
Hui, Jennie
Zhao, Jing Hua
Joshi, Peter K
Teumer, Alexande ...
Albrecht, Eva
Imboden, Medea
Rawal, Rajesh
Lopez, Lorna M
Marten, Jonathan
Enroth, Stefan
Surakka, Ida
Polasek, Ozren
Lyytikäinen, Leo ...
Granell, Raquel
Hysi, Pirro G
Flexeder, Claudi ...
Mahajan, Anubha
Beilby, John
Bossé, Yohan
Brandsma, Corry- ...
Campbell, Harry
Gieger, Christia ...
Gläser, Sven
González, Juan R
Grallert, Harald
Hammond, Chris J
Harris, Sarah E
Hartikainen, Ann ...
Heliövaara, Mark ...
Henderson, John
Hocking, Lynne
Horikoshi, Momok ...
Hutri-Kähönen, N ...
Ingelsson, Erik
Johansson, Åsa
Kemp, John P
Kolcic, Ivana
Kumar, Ashish
Lind, Lars
Melén, Erik
Musk, Arthur W
Navarro, Pau
Nickle, David C
Padmanabhan, San ...
Raitakari, Olli ...
Ried, Janina S
Ripatti, Samuli
Schulz, Holger
Scott, Robert A
Sin, Don D
Starr, John M
Viñuela, Ana
Völzke, Henry
Wild, Sarah H
Wright, Alan F
Zemunik, Tatijan ...
Jarvis, Deborah ...
Spector, Tim D
Evans, David M
Lehtimäki, Terho
Vitart, Veroniqu ...
Kähönen, Mika
Gyllensten, Ulf
Rudan, Igor
Deary, Ian J
Karrasch, Stefan
Probst-Hensch, N ...
Heinrich, Joachi ...
Stubbe, Beate
Wilson, James F
Wareham, Nichola ...
James, Alan L
Morris, Andrew P
Jarvelin, Marjo- ...
Hayward, Carolin ...
Sayers, Ian
Strachan, David ...
Hall, Ian P
Tobin, Martin D
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