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Antihypertensive tr...
Antihypertensive treatment with β-blockade in patients with asymptomatic aortic stenosis and association with cardiovascular events
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Bang, Casper N. (författare)
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Greve, Anders M. (författare)
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Rossebø, Anne B. (författare)
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visa fler...
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Ray, Simon (författare)
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Egstrup, Kenneth (författare)
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Boman, Kurt (författare)
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Nienaber, Christoph (författare)
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Okin, Peter M. (författare)
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Devereux, Richard B. (författare)
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Wachtell, Kristian (författare)
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visa färre...
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(utgivare)
- Wiley-Blackwell Publishing Inc. 2017
- 2017
- Engelska.
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Ingår i: Journal of the American Heart Association. - 2047-9980. ; 6:12
Abstract
Ämnesord
Stäng
- Background: Patients with aortic stenosis (AS) often have concomitant hypertension. Antihypertensive treatment with a beta-blocker (Bbl) is frequently avoided because of fear of depression of left ventricular function. However, it remains unclear whether antihypertensive treatment with a Bbl is associated with increased risk of cardiovascular events in patients with asymptomatic mild to moderate AS. Methods and results: We did a post hoc analysis of 1873 asymptomatic patients with mild to moderate AS and preserved left ventricular ejection fraction in the SEAS (Simvastatin and Ezetimibe in Aortic Stenosis) study. Propensity-matched Cox regression and competing risk analyses were used to assess risk ratios for all-cause mortality, sudden cardiac death, and cardiovascular death. A total of 932 (50%) patients received Bbl at baseline. During a median follow-up of 4.3 +/- 0.9 years, 545 underwent aortic valve replacement, and 205 died; of those, 101 were cardiovascular deaths, including 40 sudden cardiovascular deaths. In adjusted analyses, Bbl use was associated with lower risk of all-cause mortality (hazard ratio 0.5, 95% confidence interval 0.3-0.7, P<0.001), cardiovascular death (hazard ratio 0.4, 95% confidence interval 0.2-0.7, P<0.001), and sudden cardiac death (hazard ratio 0.2, 95% confidence interval 0.1-0.6, P=0.004). This was confirmed in competing risk analyses (all P<0.004). No interaction was detected with AS severity (all P>0.1). Conclusions: In post hoc analyses Bbl therapy did not increase the risk of all-cause mortality, sudden cardiac death, or cardiovascular death in patients with asymptomatic mild to moderate AS. A prospective study may be warranted to determine if Bbl therapy is in fact beneficial.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Cardiac and Cardiovascular Systems (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Kardiologi (hsv)
Nyckelord
- aortic valve stenosis
- arrhythmia (heart rhythm disorders)
- atrial fibrillation
- beta-blocker
- high blood essure
- hypertension
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Till lärosätets databas
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Bang, Casper N.
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Greve, Anders M.
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Rossebø, Anne B.
-
Ray, Simon
-
Egstrup, Kenneth
-
Boman, Kurt
-
visa fler...
-
Nienaber, Christ ...
-
Okin, Peter M.
-
Devereux, Richar ...
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Wachtell, Kristi ...
-
visa färre...
- Av lärosätet
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