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A Comprehensive Pan...
A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.
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Berger, Ashton C (author)
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Korkut, Anil (author)
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Kanchi, Rupa S (author)
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Hegde, Apurva M (author)
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Lenoir, Walter (author)
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Liu, Wenbin (author)
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Liu, Yuexin (author)
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Fan, Huihui (author)
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Shen, Hui (author)
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Ravikumar, Visweswaran (author)
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Rao, Arvind (author)
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Schultz, Andre (author)
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Li, Xubin (author)
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Sumazin, Pavel (author)
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- Williams, Cecilia, 1969- (author)
- KTH,Proteomik och nanobioteknologi,Cellulär och klinisk proteomik,Cecilia Williams
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Mestdagh, Pieter (author)
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Gunaratne, Preethi H (author)
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Yau, Christina (author)
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Bowlby, Reanne (author)
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Robertson, A Gordon (author)
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Tiezzi, Daniel G (author)
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Wang, Chen (author)
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Cherniack, Andrew D (author)
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Godwin, Andrew K (author)
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Kuderer, Nicole M (author)
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Rader, Janet S (author)
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Zuna, Rosemary E (author)
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Sood, Anil K (author)
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Lazar, Alexander J (author)
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Ojesina, Akinyemi I (author)
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Adebamowo, Clement (author)
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Adebamowo, Sally N (author)
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Baggerly, Keith A (author)
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Chen, Ting-Wen (author)
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Chiu, Hua-Sheng (author)
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Lefever, Steve (author)
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Liu, Liang (author)
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MacKenzie, Karen (author)
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Orsulic, Sandra (author)
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Roszik, Jason (author)
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Shelley, Carl Simon (author)
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Song, Qianqian (author)
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Vellano, Christopher P (author)
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Wentzensen, Nicolas (author)
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Weinstein, John N (author)
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Mills, Gordon B (author)
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Levine, Douglas A (author)
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Akbani, Rehan (author)
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 33:4, s. 690-705.e9
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https://doi.org/10.1...
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https://kth.diva-por... (primary) (Raw object)
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations (SCNAs) and 46 significantly mutated genes (SMGs). Eleven SCNAs and 11 SMGs had not been identified in previous TCGA studies of the individual tumor types. We found functionally significant estrogen receptor-regulated long non-coding RNAs (lncRNAs) and gene/lncRNA interaction networks. Pathway analysis identified subtypes with high leukocyte infiltration, raising potential implications for immunotherapy. Using 16 key molecular features, we identified five prognostic subtypes and developed a decision tree that classified patients into the subtypes based on just six features that are assessable in clinical laboratories.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- TCGA
- The Cancer Genome Atlas
- breast cancer
- cervical cancer
- gynecologic cancer
- omics
- ovarian cancer
- pan-gynecologic
- uterine cancer
- uterine carcinosarcoma
- Bioteknologi
- Biotechnology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Berger, Ashton C
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Korkut, Anil
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Kanchi, Rupa S
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Hegde, Apurva M
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Lenoir, Walter
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Liu, Wenbin
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show more...
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Liu, Yuexin
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Fan, Huihui
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Shen, Hui
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Ravikumar, Viswe ...
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Rao, Arvind
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Schultz, Andre
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Li, Xubin
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Sumazin, Pavel
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Williams, Cecili ...
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Mestdagh, Pieter
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Gunaratne, Preet ...
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Yau, Christina
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Bowlby, Reanne
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Robertson, A Gor ...
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Tiezzi, Daniel G
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Wang, Chen
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Cherniack, Andre ...
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Godwin, Andrew K
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Kuderer, Nicole ...
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Rader, Janet S
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Zuna, Rosemary E
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Sood, Anil K
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Lazar, Alexander ...
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Ojesina, Akinyem ...
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Adebamowo, Cleme ...
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Adebamowo, Sally ...
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Baggerly, Keith ...
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Chen, Ting-Wen
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Chiu, Hua-Sheng
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Lefever, Steve
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Liu, Liang
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MacKenzie, Karen
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Orsulic, Sandra
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Roszik, Jason
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Shelley, Carl Si ...
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Song, Qianqian
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Vellano, Christo ...
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Wentzensen, Nico ...
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Weinstein, John ...
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Mills, Gordon B
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Levine, Douglas ...
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Akbani, Rehan
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show less...
- About the subject
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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and Medicinska och f ...
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and Cell och molekyl ...
- Articles in the publication
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Cancer Cell
- By the university
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Royal Institute of Technology