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Familial aggregatio...
Familial aggregation of tinnitus : a European multicentre study
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- Hendrickx, Jan-Jaap (författare)
- Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium; Department of Otorhinolaryngology, University of Oulu, Oulu, Finland; Department of Otorhinolaryngology, UMC Nijmegen, Nijmegen, Netherlands; Department of Otolaryngology, University Hospital Antwerp, Wilrijkstraat 10, Antwerp, Belgium
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- Huyghe, Jeroen (författare)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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- Demeester, Kelly (författare)
- Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
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- Topsakal, Velat (författare)
- Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
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- Van Eyken, Els (författare)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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- Fransen, Erik (författare)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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- Mäki-Torkko, Elina (författare)
- Örebro universitet,Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Öronkliniken US,Department of Otorhinolaryngology, University of Oulu, Oulu, Finland,Institutionen för medicinska vetenskaper
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- Hannula, Samuli (författare)
- Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
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- Jensen, Mona (författare)
- Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark
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- Tropitzsch, A. (författare)
- Department of Otorhinolaryngology, University of Tübingen, Tübingen, Germany
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- Bonaconsa, Amanda (författare)
- Department of Oto-surgery, University Hospital Padova, Padova, Italy
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- Mazzoli, Manuela (författare)
- Department of Oto-surgery, University Hospital Padova, Padova, Italy,Department of Otorhinolaryngology, UMC Nijmegen, Nijmegen, Netherlands
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- Espesp, Angeles (författare)
- University Hospital of Wales, Cardiff, UK,Welsh Hearing Institute, Cardiff University, Cardiff, United Kingdom
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- Verbruggen, Katia (författare)
- Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium
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- Huyghe, Joke (författare)
- Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium
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- Huygen, Patrick (författare)
- Radboud University Nijmegen Medical Centre, the Netherlands
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- Kremer, Hannie (författare)
- Radboud University Nijmegen Medical Centre, the Netherlands,Department of Otorhinolaryngology, UMC Nijmegen, Nijmegen, Netherlands
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- Kunst, Sylvia (författare)
- Radboud University Nijmegen Medical Centre, the Netherlands,Department of Otorhinolaryngology, UMC Nijmegen, Nijmegen, Netherlands
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- Manninen, Minna (författare)
- Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
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- Diaz-Lacava, AN (författare)
- Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
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- Steffens, Michael (författare)
- Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
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- Parving, Agnete (författare)
- Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark
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- Pyykkö, Ilmari (författare)
- Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
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- Dhooge, Ingeborg (författare)
- Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium
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- Stephens, Dafydd (författare)
- University Hospital of Wales, Cardiff, UK,Welsh Hearing Institute, Cardiff University, Cardiff, United Kingdom
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- Orzan, Eva (författare)
- Department of Oto-surgery, University Hospital Padova, Padova, Italy
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- Pfister, Markus (författare)
- Department of Otorhinolaryngology, University of Tübingen, Tübingen, Germany
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- Bille, Mikael (författare)
- Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark
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- Sorri, Martti (författare)
- Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
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- Cremers, Cor (författare)
- Radboud University Nijmegen Medical Centre, the Netherlands,Department of Otorhinolaryngology, UMC Nijmegen, Nijmegen, Netherlands
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- Van Laer, Lut (författare)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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- Van Camp, Guy (författare)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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- Wienker, Thomas (författare)
- Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
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- Van de Heyning, Paul (författare)
- Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
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(creator_code:org_t)
- Louvain, Belgium : Societe Royale Belge d'Oto - Rhino - Laryngologie et de Chirurgie Cervico - Faciale, 2007
- 2007
- Engelska.
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Ingår i: B-ENT. - Louvain, Belgium : Societe Royale Belge d'Oto - Rhino - Laryngologie et de Chirurgie Cervico - Faciale. - 0001-6497. ; 3:Suppl 7, s. 51-60
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- INTRODUCTION AND AIM:Tinnitus is a common condition affecting approximately 20% of the older population. There is increasing evidence that changes in the central auditory system following cochlear malfunctioning are responsible for tinnitus. To date, few investigators have studied the influence of genetic factors on tinnitus. The present report investigates the presence of a familial effect in tinnitus subjects.METHODS:In a European multicentre study, 198 families were recruited in seven European countries. Each family had at least 3 siblings. Subjects were screened for causes of hearing loss other than presbyacusis by clinical examination and a questionnaire. The presence of tinnitus was evaluated with the question "Nowadays, do you ever get noises in your head or ear (tinnitus) which usually last longer than five minutes". Familial aggregation was tested using three methods: a mixed model approach, calculating familial correlations, and estimating the risk of a subject having tinnitus if the disorder is present in another family member.RESULTS:All methods demonstrated a significant familial effect for tinnitus. The effect persisted after correction for the effect of other risk factors such as hearing loss, gender and age. The size of the familial effect is smaller than that for age-related hearing impairment, with a familial correlation of 0.15.CONCLUSION:The presence of a familial effect for tinnitus opens the door to specific studies that can determine whether this effect is due to a shared familial environment or the involvement of genetic factors. Subsequent association studies may result in the identification of the factors responsible. In addition, more emphasis should be placed on the effect of role models in the treatment of tinnitus.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Nyckelord
- etiology
- presbyacousis
- familial aggregation
- tinnitus
- heredity
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Hendrickx, Jan-J ...
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Huyghe, Jeroen
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Demeester, Kelly
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Topsakal, Velat
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Van Eyken, Els
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Fransen, Erik
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visa fler...
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Mäki-Torkko, Eli ...
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Hannula, Samuli
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Jensen, Mona
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Tropitzsch, A.
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Bonaconsa, Amand ...
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Mazzoli, Manuela
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Espesp, Angeles
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Verbruggen, Kati ...
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Huyghe, Joke
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Huygen, Patrick
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Kremer, Hannie
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Kunst, Sylvia
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Manninen, Minna
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Diaz-Lacava, AN
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Steffens, Michae ...
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Parving, Agnete
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Pyykkö, Ilmari
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Dhooge, Ingeborg
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Stephens, Dafydd
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Orzan, Eva
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Pfister, Markus
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Bille, Mikael
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Sorri, Martti
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Cremers, Cor
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Van Laer, Lut
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Van Camp, Guy
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Wienker, Thomas
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Van de Heyning, ...
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