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IL-20 is an arterio...
IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs
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- Tritsaris, Katerina (author)
- Panum Institute, University of Copenhagen, Denmark
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- Myren, Maja (author)
- Panum Institute, University of Copenhagen, Denmark
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- Ditlev, Sisse B. (author)
- Panum Institute, University of Copenhagen, Denmark
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- Hübschmann, Martin V. (author)
- Panum Institute, University of Copenhagen, Denmark
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- van der Blom, Ida (author)
- Novo Nordisk A/S, Måløv, Denmark
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- Hansen, Anker Jon (author)
- Novo Nordisk A/S, Måløv, Denmark
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- Olsen, Uffe B. (author)
- Novo Nordisk A/S, Måløv, Denmark
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- Cao, Renhai (author)
- Karolinska Institutet
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- Zhang, Junhang (author)
- Karolinska Institutet, Stockholm, Sweden
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- Jia, Tanghong (author)
- Shandong University, Jinan, China
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- Wahlberg, Eric (author)
- Karolinska Institutet
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- Dissing, Steen (author)
- Panum Institute, University of Copenhagen, Denmark
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- Cao, Yihai (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2007-09-25
- 2007
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 104:39, s. 15364-15369
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https://urn.kb.se/re...
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Abstract
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- Successful therapeutic angiogenesis for the treatment of ischemic disorders relies on selection of optimal proangiogenic or arteriogenic agents that are able to promote establishment of functional collateral networks. Here, we show that IL-20, a pleiotropic inflammatory cytokine, displays an imperative effect on vascular remodeling. Stimulation of both large and microvascular endothelial cells with IL-20 leads to activation of receptor-dependent multiple intracellular signaling components, including increased phosphorylation levels of JAK2/STAT5, Erk1/2, and Akt; activation of small GTP-binding proteins Rac and Rho; and intracellular release of calcium. Surprisingly, IL-20 significantly promotes endothelial cell tube formation without affecting their proliferation and motility. These findings suggest that the vascular function of IL-20 involves endothelial cell organization, vessel maturation, and remodeling. Consistent with this notion, delivery of IL-20 to the ischemic muscle tissue significantly improves arteriogenesis and blood perfusion in a rat hind-limb model. Our findings provide mechanistic insights on vascular functions of IL-20 and define therapeutic implication of this cytokine for the treatment of ischemic disorders.
Keyword
- arteriogenesis; collateral growth; therapeutical angiogenesis; ischemia
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Tritsaris, Kater ...
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Myren, Maja
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Ditlev, Sisse B.
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Hübschmann, Mart ...
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van der Blom, Id ...
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Hansen, Anker Jo ...
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show more...
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Olsen, Uffe B.
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Cao, Renhai
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Zhang, Junhang
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Jia, Tanghong
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Wahlberg, Eric
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Dissing, Steen
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Cao, Yihai
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show less...
- Articles in the publication
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Proceedings of t ...
- By the university
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Linköping University
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Karolinska Institutet