International renal-cell cancer study. I. Tobacco use

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McLaughlin, J. K. (författare): National Cancer Institute, Division of Cancer Etiology, Bethesda, Maryland, United States; International Epidemiology Institute, Rockville, Maryland, United States

Lindblad, Per, 1953- (författare): Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden

McCredie, M. (författare): Cancer Epidemiology Research Unit, New South Wales Cancer Council, Kings Cross, Australia

Mandel, J. S. (författare): Division of Environmental Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States

Schlehofer, B. (författare): Division of Epidemiology, German Cancer Research Center, Heidelberg, Germany

(creator_code:org_t)

New York, USA : John Wiley & Sons, 1995
1995
Engelska.
Ingår i: International Journal of Cancer. - New York, USA : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 60:2, s. 194-198

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.1...; visa färre...

Abstract Ämnesord

Stäng

The relationship between renal-cell cancer (RCC) and tobacco use was investigated in an international, multicenter, population-based case-control study. Coordinated studies were conducted in Australia, Denmark, Germany, Sweden and the United States using a shared protocol and questionnaire. A total of 1,732 cases (1,050 men, 682 women) and 2,309 controls (1,429 men, 880 women) were interviewed for the study. No association was observed between risk and use of cigars, pipes or smokeless tobacco. A statistically significant association was observed for cigarette smoking, with current smokers having a 40% increase in risk [relative risk (RR) = 1.4, 95% confidence interval (CI) 1.2-1.7]. Risk increased with intensity (number of cigarettes) and duration (years smoked). Among current smokers the RR for pack-years rose from 1.1 (95% CI 0.8-1.5) for < 15.9 pack years to 2.0 (95% CI 1.6-2.7) for > 42 pack years (p for trend < 0.001). Long-term quitters (> 15 years) experienced a reduction in risk of about 15-25% relative to current smokers. Those who started smoking late (> 24 years of age) had about two-thirds the risk of those who started young (< or = 12 years of age). Overall, the findings of this pooled analysis confirm that cigarette smoking is a causal factor in the etiology of RCC.

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Av författaren/redakt...: McLaughlin, J. K ...; Lindblad, Per, 1 ...; Mellemgaard, A.; McCredie, M.; Mandel, J. S.; Schlehofer, B.; visa fler...; Pommer, W.; Adami, H. O.; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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