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Adjuvant Capecitabi...
Adjuvant Capecitabine, Docetaxel, Cyclophosphamide, and Epirubicin for Early Breast Cancer : Final Analysis of the Randomized FinXX Trial
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- Joensuu, Heikki (author)
- Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
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- Kellokumpu-Lehtinen, Pirkko-Liisa (author)
- Tampere University Hospital, Tampere, Finland
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- Huovinen, Riikka (author)
- Turku University Central Hospital, Turku, Finland
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- Jukkola-Vuorinen, Arja (author)
- Oulu University Hospital, Oulu, Finland
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- Tanner, Minna (author)
- Tampere University Hospital, Tampere, Finland
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- Kokko, Riitta (author)
- Kanta-Häme Central Hospital, Hämeenlinna, Finland
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- Ahlgren, Johan (author)
- Gävle Hospital, Gävle, Sweden
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- Auvinen, Paivi (author)
- Cancer Center, Kuopio University Hospital, Kuopio, Finland
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- Paija, Outi (author)
- Turku University Central Hospital, Turku, Finland
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- Helle, Leena (author)
- Kotka Central Hospital, Kotka, Finland
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- Villman, Kenneth (author)
- Region Örebro län
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- Nyandoto, Paul (author)
- Päijät-Häme Central Hospital, Lahti, Finland
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- Nilsson, Greger (author)
- Uppsala universitet,Enheten för onkologi
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- Pajunen, Marjo (author)
- Jyväskylä Central Hospital, Jyväskylä, Finland
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- Asola, Raija (author)
- Satakunta Central Hospital, Pori, Finland
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- Poikonen, Paula (author)
- Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
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- Leinonen, Mika (author)
- 4Pharma, Turku, Finland
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- Kataja, Vesa (author)
- Cancer Center, Kuopio University Hospital, Kuopio, Finland; Vaasa Central Hospital, Vaasa, Finland
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- Bono, Petri (author)
- Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
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- Lindman, Henrik (author)
- Uppsala universitet,Enheten för onkologi
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(creator_code:org_t)
- American Society of Clinical Oncology, 2012
- 2012
- English.
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In: Journal of Clinical Oncology. - : American Society of Clinical Oncology. - 0732-183X .- 1527-7755. ; 30:1, s. 11-18
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Purpose: Capecitabine is an active agent in the treatment of breast cancer. It is not known whether integration of capecitabine into an adjuvant regimen that contains a taxane, an anthracycline, and cyclophosphamide improves outcome in early breast cancer.Patients and Methods: Women with axillary node-positive or high-risk node-negative breast cancer were randomly assigned to receive either three cycles of docetaxel and capecitabine (TX) followed by three cycles of cyclophosphamide, epirubicin, and capecitabine (CEX; n = 753) or three cycles of docetaxel (T) followed by three cycles of cyclophosphamide, epirubicin, and fluorouracil (CEF; n = 747). The primary end point was recurrence-free survival (RFS).Results: During a median follow-up time of 59 months, 214 RFS events occurred (local or distant recurrences or deaths; TX/CEX, n = 96; T/CEF, n = 118). RFS was not significantly different between the groups (hazard ratio [HR], 0.79; 95% CI, 0.60 to 1.04; P = .087; 5-year RFS, 86.6% for TX/CEX v 84.1% for T/CEF). Fifty-six patients assigned to TX/CEX died during the follow-up compared with 75 of patients assigned to T/CEF (HR, 0.73; 95% CI, 0.52 to 1.04; P = .080). In exploratory analyses, TX/CEX improved breast cancer-specific survival (HR, 0.64; 95% CI, 0.44 to 0.95; P = .027) and RFS in women with triple-negative disease and in women who had more than three metastatic axillary lymph nodes at the time of diagnosis. We detected little severe late toxicity. Conclusion: Integration of capecitabine into a regimen that contains docetaxel, epirubicin, and cyclophosphamide did not improve RFS significantly compared with a similar regimen without capecitabine. J Clin Oncol 30:11-18. (c) 2011 by American Society of Clinical Oncology
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Joensuu, Heikki
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Kellokumpu-Lehti ...
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Huovinen, Riikka
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Jukkola-Vuorinen ...
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Tanner, Minna
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Kokko, Riitta
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Ahlgren, Johan
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Auvinen, Paivi
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Paija, Outi
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Helle, Leena
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Villman, Kenneth
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Nyandoto, Paul
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Nilsson, Greger
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Pajunen, Marjo
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Asola, Raija
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Poikonen, Paula
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Leinonen, Mika
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Kataja, Vesa
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Bono, Petri
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Lindman, Henrik
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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Journal of Clini ...
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Örebro University
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Uppsala University