Sökning: onr:"swepub:oai:DiVA.org:su-20419" >
Divergent asymmetri...
Divergent asymmetric synthesis of 3,5-disubstituted piperidines.
-
- Olofsson, Berit (författare)
- Stockholms universitet,Institutionen för organisk kemi
-
- Bogár, Krisztián (författare)
- Stockholms universitet,Institutionen för organisk kemi,Bäckvall
-
- Fransson, Ann-Britt L (författare)
- Stockholms universitet,Institutionen för organisk kemi,Bäckvall
-
visa fler...
-
- Bäckvall, Jan-Erling (författare)
- Stockholms universitet,Institutionen för organisk kemi
-
visa färre...
-
(creator_code:org_t)
- 2006-09-12
- 2006
- Engelska.
-
Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 71:21, s. 8256-60
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- A divergent synthesis of various 3,5-dioxygenated piperidines with interesting pharmacological properties is described. A mixture of the achiral cis- and racemic trans-3,5-piperidine diol could be efficiently obtained from N-benzylglycinate in five steps by the use of chemoenzymatic methods. In the subsequent enzyme- and Ru-catalyzed reaction, the rac/meso diol mixture was efficiently transformed to the cis-(3R,5S)-diacetate with excellent diastereoselectivity and in high yield. Further transformations of the cis-diacetate selectively delivered the cis-piperidine diol and the cis-(3R,5S)-hydroxy acetate. Alternatively, the DYKAT could be stopped at the monoacetate stage to give the trans-(3R,5R)-hydroxy acetate.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- Organic chemistry
- Organisk kemi
- organisk kemi
- Organic Chemistry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas