Is the α/β ratio for prostate tumours really low and does it vary with the level of risk at diagnosis?

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Fowler, Jack F. (författare): University of Wisconsin Medical School, Madison, WI, USA

Toma-Dasu, Iuliana (författare): Stockholms universitet,Fysikum,Stockholm University and Karolinska Institutet, Stockholm, Sweden

Dasu, Alexandru (författare): Linköpings universitet,Östergötlands Läns Landsting,Radiofysikavdelningen US,Hälsouniversitetet,Avdelningen för radiologiska vetenskaper

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International Institute of Anticancer Research (IIAR), 2013
2013
Engelska.
Ingår i: Anticancer Research. - : International Institute of Anticancer Research (IIAR). - 0250-7005 .- 1791-7530. ; 33:3, s. 1009-1011

Relaterad länk:: http://ar.iiarjourna...; visa fler...; https://urn.kb.se/re...; https://urn.kb.se/re...; visa färre...

Abstract Ämnesord

Stäng

Aim: To answer the questions: Is the α/β ratio (radiosensitivity to size of dose-per-fraction) really low enough to justify using a few large dose fractions instead of the traditional many small doses? Does this parameter vary with prognostic risk factors? Methods and Materials: Three large statistical overviews are critiqued, with results for 5,000, 6,000 and 14,000 patients with prostate carcinoma, respectively. Results: These major analyses agree in finding the average α/β ratio to be less than 2 Gy: 1.55, (95% confidence interval=0.46-4.52), 1.4 (0.9-2.2), and the third analysis 1.7 (1.4-2.2) by ASTRO and 1.6 (1.2-2.2) by Phoenix criteria. All agree that α/β values do not vary significantly with the low, intermediate, high and “all included” risk factors. Conclusion: The high sensitivity to dose-per-fraction is an intrinsic property of prostate carcinomas and this supports the use of hypofractionation to increase the therapeutic gain for these tumours with dose-volume modelling to reduce the risk of late complications in rectum and bladder.

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Av författaren/redakt...: Fowler, Jack F.; Toma-Dasu, Iulia ...; Dasu, Alexandru

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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