Sökning: onr:"swepub:oai:DiVA.org:su-87447" >
Is the α/β ratio fo...
Is the α/β ratio for prostate tumours really low and does it vary with the level of risk at diagnosis?
-
- Fowler, Jack F. (författare)
- University of Wisconsin Medical School, Madison, WI, USA
-
- Toma-Dasu, Iuliana (författare)
- Stockholms universitet,Fysikum,Stockholm University and Karolinska Institutet, Stockholm, Sweden
-
- Dasu, Alexandru (författare)
- Linköpings universitet,Östergötlands Läns Landsting,Radiofysikavdelningen US,Hälsouniversitetet,Avdelningen för radiologiska vetenskaper
-
(creator_code:org_t)
- International Institute of Anticancer Research (IIAR), 2013
- 2013
- Engelska.
-
Ingår i: Anticancer Research. - : International Institute of Anticancer Research (IIAR). - 0250-7005 .- 1791-7530. ; 33:3, s. 1009-1011
- Relaterad länk:
-
http://ar.iiarjourna...
-
visa fler...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Aim: To answer the questions: Is the α/β ratio (radiosensitivity to size of dose-per-fraction) really low enough to justify using a few large dose fractions instead of the traditional many small doses? Does this parameter vary with prognostic risk factors? Methods and Materials: Three large statistical overviews are critiqued, with results for 5,000, 6,000 and 14,000 patients with prostate carcinoma, respectively. Results: These major analyses agree in finding the average α/β ratio to be less than 2 Gy: 1.55, (95% confidence interval=0.46-4.52), 1.4 (0.9-2.2), and the third analysis 1.7 (1.4-2.2) by ASTRO and 1.6 (1.2-2.2) by Phoenix criteria. All agree that α/β values do not vary significantly with the low, intermediate, high and “all included” risk factors. Conclusion: The high sensitivity to dose-per-fraction is an intrinsic property of prostate carcinomas and this supports the use of hypofractionation to increase the therapeutic gain for these tumours with dose-volume modelling to reduce the risk of late complications in rectum and bladder.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Prostate cancer
- radiation therapy
- alapha/beta
- LQ model
- Radiation Physics
- radiofysik
- Medical Radiation Physics
- medicinsk strålningsfysik
- Oncology
- onkologi
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas