Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

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Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

Perez-Cornago, Aurora (författare): University of Oxford

Appleby, Paul N. (författare): University of Oxford

Tipper, Sarah (författare): University of Oxford

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Key, Timothy J. (författare): University of Oxford

Allen, Naomi E. (författare): University of Oxford

Nieters, Alexandra (författare): University Medical Center Freiburg

Vermeulen, Roel (författare): Utrecht University

Roulland, Sandrine (författare): Centre d'Immunologie Marseille Luminy

Casabonne, Delphine (författare): Bellvitge Biomedical Research Institute

Kaaks, Rudolf (författare): German Cancer Research Centre

Fortner, Renee T. (författare): German Cancer Research Centre

Boeing, Heiner (författare): German Institute of Human Nutrition

Trichopoulou, Antonia (författare): National and Kapodistrian University of Athens

La Vecchia, Carlo (författare): University of Milan

Klinaki, Eleni (författare)

Hansen, Louise (författare): Danish Cancer Society

Tjonneland, Anne (författare): Danish Cancer Society

Bonnet, Fabrice (författare): Rennes University Hospital

Fagherazzi, Guy (författare): University of Paris-Saclay

Boutron-Ruault, Marie-Christine (författare): University of Paris-Saclay

Pala, Valeria (författare): Istituto Nazionale dei Tumori

Masala, Giovanna (författare): Cancer Research and Prevention Institute (ISPO)

Sacerdote, Carlotta (författare): Citta' della Salute e della Scienza Hospital-University of Turin

Peeters, Petra H. (författare): MRC Human Nutrition Research

Bueno-de-Mesquita, H. B(as) (författare): University of Malaya

Weiderpass, Elisabete (författare): Karolinska Institutet,Folkhälsan Research Center

Dorronsoro, Miren (författare): CIBER Epidemiology and Public Health (CIBERESP)

Quiros, J. Ramon (författare)

Barricarte, Aurelio (författare): Health Research Institute of Navarra (IDISNA)

Gavrila, Diana (författare): Murcia Regional Health Council

Agudo, Antonio (författare): Bellvitge Biomedical Research Institute

Borgquist, Signe (författare): Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine

Rosendahl, Ann H. (författare): Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine

Melin, Beatrice (författare): Umeå University,Umeå universitet,Onkologi

Wareham, Nick (författare): University of Cambridge

Khaw, Kay-Tee (författare): University of Cambridge

Gunter, Marc (författare): International Agency for Research on Cancer, World Health Organization

Riboli, Elio (författare): Imperial College London

Vineis, Paolo (författare): Imperial College London

Travis, Ruth C. (författare): University of Oxford

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(creator_code:org_t)

2016-12-27
2017
Engelska.
Ingår i: International Journal of Cancer. - : WILEY-BLACKWELL. - 0020-7136 .- 1097-0215. ; 140:5, s. 1111-1118

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://onlinelibrar...; http://dx.doi.org/10... (free); https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; https://lup.lub.lu.s...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third = 0.77 [95% CI = 0.57-1.03], p(trend) = 0.06). There was no statistical evidence of heterogeneity in this association with IGF-I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (pheterogeneity for all >= 0.05). There were no associations between IGF-I concentration and risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF-I concentrations and risk of lymphoma. Further What's new? Insulin-like growth factor I does not appear to influence lymphoma risk, according to new results. IGF-I can promote some cancers, but there hasn't been a prospective epidemiological study examining the link between IGF-I concentration and lymphoma risk. To uncover a link, these authors arranged a NESTED case-control study with participants from the European Prospective Investigation into Cancer and Nutrition (EPIC). They tested for IGF-I in pre-diagnosis samples and found no association between the factor and overall lymphoma risk, nor with any subtype, although the number of cases was small for each subtype, and further studies are necessary.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

prospective
lymphoma
non-Hodgkin lymphoma
plasma
IGF-I
EPIC cohort
nested case-control
EPIC cohort
IGF-I
Lymphoma
Nested case-control
Non-Hodgkin lymphoma
Plasma
Prospective

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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Av lärosätet: Umeå universitet; Karolinska Institutet; Lunds universitet

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