Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Search: onr:"swepub:oai:DiVA.org:umu-162898" > Elevated Platelet C...

1 of 1
Previous record
Next record
To hitlist

Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer : A Mendelian Randomization Analysis

Zhu, Ying (author): Nanjing Medical University

Wei, Yongyue (author)

Zhang, Ruyang (author)

Dong, Xuesi (author)

Shen, Sipeng (author)

Zhao, Yang (author)

Bai, Jianling (author)

Albanes, Demetrius (author)

Caporaso, Neil E. (author)

Landi, Maria Teresa (author)

Zhu, Bin (author)

Chanock, Stephen J. (author)

Gu, Fangyi (author)

Lam, Stephen (author)

Tsao, Ming-Sound (author)

Shepherd, Frances A. (author)

Tardon, Adonina (author)

Fernandez-Somoano, Ana (author)

Fernandez-Tardon, Guillermo (author)

Chen, Chu (author): Harvard University,Nanjing Medical University

Barnett, Matthew J. (author)

Doherty, Jennifer (author)

Bojesen, Stig E. (author)

Johansson, Mattias (author)

Brennan, Paul (author)

Mckay, James D. (author)

Carreras-Torres, Robert (author)

Muley, Thomas (author)

Risch, Angela (author)

Wichmann, Heunz-Erich (author)

Bickeboeller, Heike (author)

Rosenberger, Albert (author)

Rennert, Gad (author)

Saliba, Walid (author)

Arnold, Susanne M. (author)

Field, John K. (author)

Davies, Michael P. A. (author)

Marcus, Michael W. (author)

Wu, Xifeng (author)

Ye, Yuanqing (author)

Le Marchand, Loic (author)

Wilkens, Lynne R. (author)

Melander, Olle (author): Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups

Manjer, Jonas (author): Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups

Brunnström, Hans (author): Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups

Hung, Rayjean J. (author)

Liu, Geoffrey (author)

Brhane, Yonathan (author)

Kachuri, Linda (author)

Andrew, Angeline S. (author)

Duell, Eric J. (author)

Kiemeney, Lambertus A. (author)

van der Heijden, Erik H. F. M. (author)

Haugen, Aage (author)

Zienolddiny, Shanbeh (author)

Skaug, Vidar (author)

Grankvist, Kjell (author): Umeå universitet,Klinisk kemi

Johansson, Mikael (author): Umeå universitet,Onkologi

Woll, Penella J. (author)

Cox, Angela (author)

Taylor, Fiona (author)

Teare, Dawn M. (author)

Lazarus, Philip (author)

Schabath, Matthew B. (author)

Aldrich, Melinda C. (author)

Houlston, Richard S. (author)

McLaughlin, John (author)

Stevens, Victoria L. (author)

Shen, Hongbing (author)

Hu, Zhibin (author)

Dai, Juncheng (author)

Amos, Christopher I. (author)

Han, Younghun (author)

Zhu, Dakai (author)

Goodman, Gary E. (author)

Chen, Feng (author)

Christiani, David C. (author)

show less...

(creator_code:org_t)

et al

American Association for Cancer Research (AACR), 2019
2019
English.
In: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 28:5, s. 935-942

Related links:: http://dx.doi.org/10...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; https://lup.lub.lu.s...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear. Methods: We performed single and combined multiple instrumental variable Mendelian randomization analysis by an inverse-weighted method, in addition to a series of sensitivity analyses. Summary data for associations between SNPs and platelet count are from a recent publication that included 48,666 Caucasian Europeans, and the International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls to analyze associations between candidate SNPs and lung cancer risk. Results: Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall nonsmall cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15-2.27; P = 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27-7.06; P = 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings. Conclusions: Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention. Impact: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.

Find in a library

Cancer Epidemiology, Biomarkers and Prevention (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Zhu, Ying; Wei, Yongyue; Zhang, Ruyang; Dong, Xuesi; Shen, Sipeng; Zhao, Yang; show more...; Bai, Jianling; Albanes, Demetri ...; Caporaso, Neil E ...; Landi, Maria Ter ...; Zhu, Bin; Chanock, Stephen ...; Gu, Fangyi; Lam, Stephen; Tsao, Ming-Sound; Shepherd, France ...; Tardon, Adonina; Fernandez-Somoan ...; Fernandez-Tardon ...; Chen, Chu; Barnett, Matthew ...; Doherty, Jennife ...; Bojesen, Stig E.; Johansson, Matti ...; Brennan, Paul; Mckay, James D.; Carreras-Torres, ...; Muley, Thomas; Risch, Angela; Wichmann, Heunz- ...; Bickeboeller, He ...; Rosenberger, Alb ...; Rennert, Gad; Saliba, Walid; Arnold, Susanne ...; Field, John K.; Davies, Michael ...; Marcus, Michael ...; Wu, Xifeng; Ye, Yuanqing; Le Marchand, Loi ...; Wilkens, Lynne R ...; Melander, Olle; Manjer, Jonas; Brunnström, Hans; Hung, Rayjean J.; Liu, Geoffrey; Brhane, Yonathan; Kachuri, Linda; Andrew, Angeline ...; Duell, Eric J.; Kiemeney, Lamber ...; van der Heijden, ...; Haugen, Aage; Zienolddiny, Sha ...; Skaug, Vidar; Grankvist, Kjell; Johansson, Mikae ...; Woll, Penella J.; Cox, Angela; Taylor, Fiona; Teare, Dawn M.; Lazarus, Philip; Schabath, Matthe ...; Aldrich, Melinda ...; Houlston, Richar ...; McLaughlin, John; Stevens, Victori ...; Shen, Hongbing; Hu, Zhibin; Dai, Juncheng; Amos, Christophe ...; Han, Younghun; Zhu, Dakai; Goodman, Gary E.; Chen, Feng; Christiani, Davi ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

Articles in the publication: Cancer Epidemiol ...

By the university: Umeå University; Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer : A Mendelian Randomization Analysis

Subject headings

Publication and Content Type

Find in a library

To the university's database

Find more in SwePub

Search outside SwePub