Mixtures of persistent organic pollutants are found in vital organs of late gestation human fetuses

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Mixtures of persistent organic pollutants are found in vital organs of late gestation human fetuses

Björvang, Richelle D. (författare): Karolinska Institute,Karolinska Institutet,Karolinska University Hospital

Vinnars, Marie-Therese (författare): Umeå University,Karolinska Institute,Umeå universitet,Obstetrik och gynekologi,Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden; Division of Obstetrics and Gynecology Ornsköldsviks Hospital, Sweden

Papadogiannakis, Nikos (författare): Karolinska Institute,Karolinska Institutet,Karolinska University Hospital

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Gidlöf, Sebastian (författare): Karolinska Institute,Karolinska Institutet,Karolinska University Hospital

Mamsen, Linn Salto (författare): Laboratory of Reproductive Biology, Section 5712, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen and University of Copenhagen, Rigshospitalet, Copenhagen, Denmark

Mucs, Daniel (författare): Karolinska Institute

Kiviranta, Hannu (författare): Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland,Finnish National Institute for Health and Welfare

Rantakokko, Panu (författare): Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland,Finnish National Institute for Health and Welfare

Ruokojärvi, Päivi (författare): Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland,Finnish National Institute for Health and Welfare

Lindh, Christian H. (författare): Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine

Andersen, Claus Yding (författare): Laboratory of Reproductive Biology, Section 5712, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen and University of Copenhagen, Rigshospitalet, Copenhagen, Denmark

Damdimopoulou, Pauliina (författare): Karolinska Institute,Karolinska Institutet,Karolinska University Hospital

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Elsevier, 2021
2021
Engelska.
Ingår i: Chemosphere. - : Elsevier. - 0045-6535 .- 1879-1298. ; 283

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://doi.org/10.1...; http://dx.doi.org/10... (free); https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; https://lup.lub.lu.s...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Persistent organic pollutants (POPs) are industrial chemicals with long half-lives. Early life exposure to POPs has been associated with adverse effects. Fetal exposure is typically estimated based on concentrations in maternal serum or placenta and little is known on the actual fetal exposure. We measured the concentrations of nine organochlorine pesticides (OCPs), ten polychlorinated biphenyl (PCB) congeners, and polybrominated diphenyl ether (PBDE) congeners by gas chromatography – tandem mass spectrometry in maternal serum, placenta, and fetal tissues (adipose tissue, liver, heart, lung and brain) in 20 pregnancies that ended in stillbirth (gestational weeks 36–41). The data were combined with our earlier data on perfluoroalkyl substances (PFASs) in the same cohort (Mamsen et al. 2019). HCB, p,p’-DDE, PCB 138 and PCB 153 were quantified in all samples of maternal serum, placenta and fetal tissues. All 22 POPs were detected in all fetal adipose tissue samples, even in cases where they could not be detected in maternal serum or placenta. Tissue:serum ratios were significantly higher in later gestations, male fetuses, and pregnancies with normal placental function. OCPs showed the highest tissue:serum ratios and PFAS the lowest. The highest chemical burden was found in adipose tissue and lowest in the brain. Overall, all studied human fetuses were intrinsically exposed to mixtures of POPs. Tissue:serum ratios were significantly modified by gestational age, fetal sex and placental function. Importantly, more chemicals were detected in fetal tissues compared to maternal serum and placenta, implying that these proxy samples may provide a misleading picture of actual fetal exposures.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)

Nyckelord

Human fetal exposure
Organochlorine pesticides
Perfluoroalkyl substances
Persistent organic pollutants
Polybrominated diphenyl ether
Polychlorinated biphenyls
Human fetal exposure
Organochlorine pesticides
Perfluoroalkyl substances
Persistent organic pollutants
Polybrominated diphenyl ether
Polychlorinated biphenyls

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Av lärosätet: Umeå universitet; Karolinska Institutet; Lunds universitet

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