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Platelet MAO-B, personality, and psychopathology
- Ruchkin, Vladislav V (author)
- Koposov, Roman A (author)
-
- af Klinteberg, Britt (author)
- Stockholms universitet,Centrum för forskning om ojämlikhet i hälsa (CHESS),Psykologiska institutionen
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- Grigorenko, Elena L (author)
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- (creator_code:org_t)
- 2005
- 2005
- English.
- In: Journal of Abnormal Psychology. - 0021-843X .- 1939-1846. ; 114:3, s. 477-482
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The article investigates the relationships between platelet monoamine oxidase-B (MAO-B) activity, personality, and psychopathology (Diagnostic and Statistical Manual of Mental Disorders [4th ed.; American Psychiatric Association, 1994] diagnoses. These relationships were assessed in 178 incarcerated male juvenile delinquents. Even after controlling for smoking, the authors found that both Internalizing and Externalizing Psychopathology were negatively related to MAO-B activity. In the final reduced model, novelty seeking fully mediated the relationships between MAO-B and Externalizing Psychopathology but not between MAO-B and Internalizing Psychopathology. It was hypothesized that low platelet MAO-B activity does not directly predispose individuals to psychopathology but is related to specific personality traits, which in turn represent a vulnerability factor for psychopathology. Future studies should help clarify the nature of the relationships between personality, biological markers, and psychopathology.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Keyword
- juvenile delinquents
- platelet MAO-B
- psychopathology
- personality
- novelty seeking
- MEDICINE
- MEDICIN
- Psychology
- Psykologi
- psykologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- SOCIAL SCIENCES
- SOCIAL SCIENCES
- and Psychology
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- Uppsala University
- Karolinska Institutet
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