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Patient- and proxy-...
Patient- and proxy-reported utility in Alzheimer disease using the EuroQoL
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- Jönsson, Linus (författare)
- Karolinska Institutet
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- Andreasen, Niels (författare)
- Karolinska Institutet
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- Kilander, Lena (författare)
- Uppsala universitet,Geriatrik
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Soininen, Hilkka (författare)
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Waldemar, Gunhild (författare)
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Nygaard, Harald (författare)
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- Winblad, Bengt (författare)
- Karolinska Institutet
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- Eriksdotter Jönhagen, Maria (författare)
- Karolinska Institutet
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Hallikainen, Merja (författare)
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- Wimo, Anders (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2006
- 2006
- Engelska.
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Ingår i: Alzheimer Disease and Associated Disorders. - : Ovid Technologies (Wolters Kluwer Health). - 0893-0341 .- 1546-4156. ; 20:1, s. 49-55
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- This study aims to compare patient- and proxy-rated utilities and health-related quality of life from individuals in different stages of Alzheimer disease (AD). Two hundred seventy-two patients and their primary caregivers were enrolled in a prospective observational study and underwent three consecutive interviews, 6 months apart. Average Mini-Mental State Examination (MMSE) scores were 19.3, 18.0, and 16.4 at the three interviews; scores ranged from 0 to 30. Using the EuroQoL EQ-5D instrument, patient-rated health utilities were on average 0.833 with little variation across MMSE-based severity levels. Proxy-rated health utilities were 0.69 (MMSE >25), 0.64 (MMSE 21-25), 0.50 (MMSE 15-20), 0.49 (MMSE 10-14), and 0.33 (MMSE <10). Proxy-rated utilities, as well as changes in utilities over time, were significantly related to MMSE scores and inversely related to scores on a brief version of the neuropsychiatric inventory (NPI) and institutionalization. Utilities were highly correlated with the disease-specific quality of life instrument QoL-AD. The study shows that the EuroQoL can be used to rate utilities in Alzheimer disease, but there are important differences between patient- and proxy-ratings.
Nyckelord
- MEDICINE
- MEDICIN
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- ref (ämneskategori)
- art (ämneskategori)
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