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CUBN Is a Gene Locus for Albuminuria

Boeger, Carsten A. (author)
Chen, Ming-Huei (author)
Tin, Adrienne (author)
show more...
Olden, Matthias (author)
Koettgen, Anna (author)
de Boer, Ian H. (author)
Fuchsberger, Christian (author)
O'Seaghdha, Conall M. (author)
Pattaro, Cristian (author)
Teumer, Alexander (author)
Liu, Ching-Ti (author)
Glazer, Nicole L. (author)
Li, Man (author)
O'Conne, Jeffrey R. (author)
Tanaka, Toshiko (author)
Peralta, Carmen A. (author)
Kutalik, Zoltan (author)
Luan, Jian'an (author)
Zhao, Jing Hua (author)
Hwang, Shih-Jen (author)
Akylbekova, Ermeg (author)
Kramer, Holly (author)
van der Harst, Pim (author)
Smith, Albert V. (author)
Lohman, Kurt (author)
de Andrade, Mariza (author)
Hayward, Caroline (author)
Kollerits, Barbara (author)
Toenjes, Anke (author)
Aspelund, Thor (author)
Ingelsson, Erik (author)
Karolinska Institutet
Eiriksdottir, Gudny (author)
Launer, Lenore J. (author)
Harris, Tamara B. (author)
Shuldiner, Alan R. (author)
Mitchell, Braxton D. (author)
Arking, Dan E. (author)
Franceschini, Nora (author)
Boerwinkle, Eric (author)
Egan, Josephine (author)
Hernandez, Dena (author)
Reilly, Muredach (author)
Townsend, Raymond R. (author)
Lumley, Thomas (author)
Siscovick, David S. (author)
Psaty, Bruce M. (author)
Kestenbaum, Bryan (author)
Haritunians, Talin (author)
Bergmann, Sven (author)
Vollenweider, Peter (author)
Waeber, Gerard (author)
Mooser, Vincent (author)
Waterworth, Dawn (author)
Johnson, Andrew D. (author)
Florez, Jose C. (author)
Meigs, James B. (author)
Lu, Xiaoning (author)
Turner, Stephen T. (author)
Atkinson, Elizabeth J. (author)
Leak, Tennille S. (author)
Aasarod, Knut (author)
Skorpen, Frank (author)
Syvänen, Ann-Christine (author)
Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
Illig, Thomas (author)
Baumert, Jens (author)
Koenig, Wolfgang (author)
Kraemer, Bernhard K. (author)
Devuyst, Olivier (author)
Mychaleckyj, Josyf C. (author)
Minelli, Cosetta (author)
Bakker, Stephan J. L. (author)
Kedenko, Lyudmyla (author)
Paulweber, Bernhard (author)
Coassin, Stefan (author)
Endlich, Karlhans (author)
Kroemer, Heyo K. (author)
Biffar, Reiner (author)
Stracke, Sylvia (author)
Voelzke, Henry (author)
Stumvol, Michael (author)
Maegi, Reedik (author)
Campbell, Harry (author)
Vitart, Veronique (author)
Hastie, Nicholas D. (author)
Gudnason, Vilmundur (author)
Kardia, Sharon L. R. (author)
Liu, Yongmei (author)
Polasek, Ozren (author)
Curhan, Gary (author)
Kronenberg, Florian (author)
Prokopenko, Inga (author)
Rudan, Igor (author)
Ärnlöv, Johan (author)
Högskolan Dalarna,Uppsala universitet,Geriatrik,Medicinsk vetenskap
Hallan, Stein (author)
Navis, Gerjan (author)
Parsa, Afshin (author)
Ferrucci, Luigi (author)
Coresh, Josef (author)
Shlipak, Michael G. (author)
Bul, Shelley B. (author)
Paterson, Andrew D. (author)
Wichmann, H. -Erich (author)
Wareham, Nicholas J. (author)
Loos, Ruth J. F. (author)
Rotter, Jerome I. (author)
Pramstaller, Peter P. (author)
Cupples, L. Adrienne (author)
Beckmann, Jacques S. (author)
Yang, Qiong (author)
Heid, Iris M. (author)
Rettig, Rainer (author)
Dreisbach, Albert W. (author)
Bochud, Murielle (author)
Fox, Caroline S. (author)
Kao, W. H. L. (author)
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 (creator_code:org_t)
2011
2011
English.
In: Journal of the American Society of Nephrology. - 1046-6673 .- 1533-3450. ; 22:3, s. 555-570
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants on albuminuria in both general and diabetic populations. We performed a meta-analysis of data from 63,153 individuals of European ancestry with genotype information from genome-wide association studies (CKDGen Consortium) and from a large candidate gene study (CARe Consortium) to identify susceptibility loci for the quantitative trait urinary albumin-to-creatinine ratio (UACR) and the clinical diagnosis microalbuminuria. We identified an association between a missense variant (I2984V) in the CUBN gene, which encodes cubilin, and both UACR (P = 1.1 x 10(-11)) and microalbuminuria (P = 0.001). We observed similar associations among 6981 African Americans in the CARe Consortium. The associations between this variant and both UACR and microalbuminuria were significant in individuals of European ancestry regardless of diabetes status. Finally, this variant associated with a 41% increased risk for the development of persistent microalbuminuria during 20 years of follow-up among 1304 participants with type 1 diabetes in the prospective DCCT/EDIC Study. In summary, we identified a missense CUBN variant that associates with levels of albuminuria in both the general population and in individuals with diabetes.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Keyword

MEDICINE
MEDICIN
Hälsa och välfärd

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Boeger, Carsten ...
Chen, Ming-Huei
Tin, Adrienne
Olden, Matthias
Koettgen, Anna
de Boer, Ian H.
show more...
Fuchsberger, Chr ...
O'Seaghdha, Cona ...
Pattaro, Cristia ...
Teumer, Alexande ...
Liu, Ching-Ti
Glazer, Nicole L ...
Li, Man
O'Conne, Jeffrey ...
Tanaka, Toshiko
Peralta, Carmen ...
Kutalik, Zoltan
Luan, Jian'an
Zhao, Jing Hua
Hwang, Shih-Jen
Akylbekova, Erme ...
Kramer, Holly
van der Harst, P ...
Smith, Albert V.
Lohman, Kurt
de Andrade, Mari ...
Hayward, Carolin ...
Kollerits, Barba ...
Toenjes, Anke
Aspelund, Thor
Ingelsson, Erik
Eiriksdottir, Gu ...
Launer, Lenore J ...
Harris, Tamara B ...
Shuldiner, Alan ...
Mitchell, Braxto ...
Arking, Dan E.
Franceschini, No ...
Boerwinkle, Eric
Egan, Josephine
Hernandez, Dena
Reilly, Muredach
Townsend, Raymon ...
Lumley, Thomas
Siscovick, David ...
Psaty, Bruce M.
Kestenbaum, Brya ...
Haritunians, Tal ...
Bergmann, Sven
Vollenweider, Pe ...
Waeber, Gerard
Mooser, Vincent
Waterworth, Dawn
Johnson, Andrew ...
Florez, Jose C.
Meigs, James B.
Lu, Xiaoning
Turner, Stephen ...
Atkinson, Elizab ...
Leak, Tennille S ...
Aasarod, Knut
Skorpen, Frank
Syvänen, Ann-Chr ...
Illig, Thomas
Baumert, Jens
Koenig, Wolfgang
Kraemer, Bernhar ...
Devuyst, Olivier
Mychaleckyj, Jos ...
Minelli, Cosetta
Bakker, Stephan ...
Kedenko, Lyudmyl ...
Paulweber, Bernh ...
Coassin, Stefan
Endlich, Karlhan ...
Kroemer, Heyo K.
Biffar, Reiner
Stracke, Sylvia
Voelzke, Henry
Stumvol, Michael
Maegi, Reedik
Campbell, Harry
Vitart, Veroniqu ...
Hastie, Nicholas ...
Gudnason, Vilmun ...
Kardia, Sharon L ...
Liu, Yongmei
Polasek, Ozren
Curhan, Gary
Kronenberg, Flor ...
Prokopenko, Inga
Rudan, Igor
Ärnlöv, Johan
Hallan, Stein
Navis, Gerjan
Parsa, Afshin
Ferrucci, Luigi
Coresh, Josef
Shlipak, Michael ...
Bul, Shelley B.
Paterson, Andrew ...
Wichmann, H. -Er ...
Wareham, Nichola ...
Loos, Ruth J. F.
Rotter, Jerome I ...
Pramstaller, Pet ...
Cupples, L. Adri ...
Beckmann, Jacque ...
Yang, Qiong
Heid, Iris M.
Rettig, Rainer
Dreisbach, Alber ...
Bochud, Murielle
Fox, Caroline S.
Kao, W. H. L.
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
Articles in the publication
Journal of the A ...
By the university
Uppsala University
Karolinska Institutet
Högskolan Dalarna

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