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Mutations in DMRT3 ...
Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice
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- Andersson, Lisa (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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- Larhammar, Martin (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
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- Memic, Fatima (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
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- Wootz, Hanna (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
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- Schwochow, Doreen (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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- Rubin, Carl-Johan (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Patra, Kalicharan (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
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Arnason, Thorvaldur (author)
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Wellbring, Lisbeth (author)
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- Hjälm, Göran (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Imsland, Freyja (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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Petersen, Jessica L. (author)
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McCue, Molly E. (author)
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Mickelson, James R. (author)
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Cothran, Gus (author)
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Ahituv, Nadav (author)
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- Roepstorff, Lars (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB)
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- Mikko, Sofia (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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- Vallstedt, Anna (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
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- Lindgren, Gabriella (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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- Andersson, Leif (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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- Kullander, Klas (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
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(creator_code:org_t)
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- 2012-08-29
- 2012
- English.
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 488:7413, s. 642-646
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Locomotion in mammals relies on a central pattern-generating circuitry of spinal interneurons established during development that coordinates limb movement(1). These networks produce left-right alternation of limbs as well as coordinated activation of flexor and extensor muscles(2). Here we show that a premature stop codon in the DMRT3 gene has a major effect on the pattern of locomotion in horses. The mutation is permissive for the ability to perform alternate gaits and has a favourable effect on harness racing performance. Examination of wild-type and Dmrt3-null mice demonstrates that Dmrt3 is expressed in the dI6 subdivision of spinal cord neurons, takes part in neuronal specification within this subdivision, and is critical for the normal development of a coordinated locomotor network controlling limb movements. Our discovery positions Dmrt3 in a pivotal role for configuring the spinal circuits controlling stride in vertebrates. The DMRT3 mutation has had a major effect on the diversification of the domestic horse, as the altered gait characteristics of a number of breeds apparently require this mutation.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Genetik och förädling inom lantbruksvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Genetics and Breeding in Agricultural Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nature
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To the university's database
- By the author/editor
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Andersson, Lisa
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Larhammar, Marti ...
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Memic, Fatima
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Wootz, Hanna
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Schwochow, Doree ...
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Rubin, Carl-Joha ...
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show more...
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Patra, Kalichara ...
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Arnason, Thorval ...
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Wellbring, Lisbe ...
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Hjälm, Göran
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Imsland, Freyja
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Petersen, Jessic ...
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McCue, Molly E.
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Mickelson, James ...
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Cothran, Gus
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Ahituv, Nadav
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Roepstorff, Lars
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Mikko, Sofia
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Vallstedt, Anna
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Lindgren, Gabrie ...
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Andersson, Leif
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Kullander, Klas
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agricultural Bio ...
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and Genetics and Bre ...
- Articles in the publication
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Nature
- By the university
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Uppsala University
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Swedish University of Agricultural Sciences