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Autoimmune and Atop...
Autoimmune and Atopic Disorders and Risk of Classical Hodgkin Lymphoma
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- Hollander, Peter (author)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
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- Rostgaard, Klaus (author)
- Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen S, Denmark.
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- Smedby, Karin E. (author)
- Karolinska Institutet
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- Chang, Ellen T. (author)
- Stanford Univ, Sch Med, Dept Hlth Res & Policy, Div Epidemiol, Stanford, CA 94305 USA.;Exponent Inc, Hlth Sci, Menlo Pk, CA USA.
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- Amini, Rose-Marie (author)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
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- Brown, Peter de Nully (author)
- Rigshosp, Dept Haematol, DK-2100 Copenhagen, Denmark.
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- Glimelius, Bengt (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Adami, Hans-Olov (author)
- Karolinska Institutet
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- Melbye, Mads (author)
- Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA.
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- Glimelius, Ingrid (author)
- Karolinska Institutet,Uppsala universitet,Experimentell och klinisk onkologi
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- Hjalgrim, Henrik (author)
- Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen S, Denmark.
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(creator_code:org_t)
- 2015-09-06
- 2015
- English.
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In: American Journal of Epidemiology. - : Oxford University Press (OUP). - 0002-9262 .- 1476-6256. ; 182:7, s. 624-632
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Abstract
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- Results from previous investigations have shown associations between the risk of Hodgkin lymphoma (HL) and a history of autoimmune and atopic diseases, but it remains unknown whether these associations apply to all types of HL or only to specific subtypes. We investigated immune diseases and the risk of classical HL in a population-based case-control study that included 585 patients and 3,187 controls recruited from October 1999 through August 2002. We collected information on immune diseases through telephone interviews and performed serological analyses of specific immunoglobulin E reactivity. Tumor Epstein-Barr virus (EBV) status was determined for 498 patients. Odds ratios with 95% confidence intervals were calculated using logistic regression analysis. Rheumatoid arthritis was associated with a higher risk of HL (odds ratio (OR) = 2.63; 95% confidence interval (CI): 1.47, 4.70), especially EBV-positive HL (OR = 3.18; 95% CI: 1.23, 8.17), and with mixed-cellularity HL (OR = 4.25; 95% CI: 1.66, 10.90). HL risk was higher when we used proxies of severe rheumatoid arthritis, such as ever having received daily rheumatoid arthritis medication (OR = 3.98; 95% CI: 2.08, 7.62), rheumatoid arthritis duration of 6-20 years (OR = 3.80; 95% CI: 1.72, 8.41), or ever having been hospitalized for rheumatoid arthritis (OR = 7.36; 95% CI: 2.95, 18.38). Atopic diseases were not associated with the risk of HL. EBV replication induced by chronic inflammation in patients with autoimmune diseases might explain the higher risk of EBV-positive HL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- atopic hypersensitivity
- Epstein-Barr virus
- Hodgkin lymphoma
- primary Sjogren's syndrome
- rheumatoid arthritis
- systemic lupus erythematosus
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hollander, Peter
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Rostgaard, Klaus
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Smedby, Karin E.
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Chang, Ellen T.
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Amini, Rose-Mari ...
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Brown, Peter de ...
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Glimelius, Bengt
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Adami, Hans-Olov
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Melbye, Mads
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Glimelius, Ingri ...
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Hjalgrim, Henrik
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Uppsala University
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Karolinska Institutet