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Sökning: onr:"swepub:oai:DiVA.org:uu-359660" > Maternal age at del...

Maternal age at delivery, lung function and asthma in offspring : a population-based survey

Real, Francisco Gomez (författare)
Univ Bergen, Dept Clin Sci, N-5020 Bergen, Norway;Haukeland Hosp, Dept Obstet & Gynaecol, Bergen, Norway
Burgess, John A. (författare)
Villani, Simona (författare)
Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia;Univ Pavia, Dept Publ Hlth Expt & Forens Med, Unit Biostat & Clin Epidemiol, Pavia, Italy
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Dratva, Julia (författare)
Swiss Trop Inst, Inst Social & Prevent Med, Basel, Switzerland
Heinrich, Joachim (författare)
Natl Res Ctr Environm & Hlth, Mol Epidemiol, Forschungszentrum Umwelt & Gesundheit, Neuherberg, Germany
Janson, Christer (författare)
Uppsala universitet,Lung- allergi- och sömnforskning
Jarvis, Debbie (författare)
Imperial Coll, Dept Publ Hlth Sci, London, England
Koplin, Jennifer (författare)
Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia
Leynaert, Benedicte (författare)
Inserm, UMR 1152, Pathophysiol & Epidemiol Resp Dis, Paris, France;Univ Paris Diderot Paris 7, Paris, France
Lodge, Caroline (författare)
Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia
Laerum, Birger N. (författare)
Univ Bergen, Dept Clin Sci, N-5020 Bergen, Norway
Matheson, Melanie C. (författare)
Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia
Norbäck, Dan (författare)
Uppsala universitet,Lung- allergi- och sömnforskning
Omenaas, Ernst R. (författare)
Univ Bergen, Dept Clin Sci, N-5020 Bergen, Norway;Haukeland Hosp, Ctr Clin Res, Bergen, Norway
Skulstad, Svein M. (författare)
Univ Bergen, Dept Clin Sci, N-5020 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway
Sunyer, Jordi (författare)
Ctr Recerca Epidemiol & Ambiental, Barcelona, Spain
Dharmage, Shyamali C. (författare)
Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia
Svanes, Cecilie (författare)
Haukeland Hosp, Dept Occupat Med, Bergen, Norway;Univ Bergen, Ctr Int Hlth, Bergen, Norway
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 (creator_code:org_t)
2018-06-07
2018
Engelska.
Ingår i: European Respiratory Journal. - : EUROPEAN RESPIRATORY SOC JOURNALS LTD. - 0903-1936 .- 1399-3003. ; 51:6
Relaterad länk:
https://erj.ersjourn...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • There is limited information about potential impact of maternal age on the respiratory health of offspring. We investigated the association of maternal age at delivery with adult offspring's lung function, respiratory symptoms and asthma, and potential differences according to offspring sex. 10 692 adults from 13 countries participating in the European Community Respiratory Health Survey (ECRHS) II responded to standardised interviews and provided lung function measurements and serum for IgE measurements at age 25-55 years. In logistic and linear multilevel mixed models we adjusted for participants' characteristics (age, education, centre, number of older siblings) and maternal characteristics (smoking in pregnancy, education) while investigating for differential effects by sex. Maternal age was validated in a subsample using data from the Norwegian birth registry. Increasing maternal age was associated with increasing forced expiratory volume in 1 s (2.33 mL per year, 95% CI 0.34-4.32 mL per year), more consistent in females (p(trend) 0.025) than in males (ptrend 0.14). Asthma (OR 0.85, 95% CI 0.79-0.92) and respiratory symptoms (OR 0.87, 95% CI 0.82-0.92) decreased with increasing maternal age (per 5 years) in females, but not in males (p(interaction) 0.05 and 0.001, respectively). The results were consistent across centres and not explained by confounding factors. Maternal ageing was related to higher adult lung function and less asthma/symptoms in females. Biological characteristics in offspring related to maternal ageing are plausible and need further investigation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

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