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Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma

Radivoyevitch, Tomas (author)
Cleveland Clin Fdn, Dept Quantitat Hlth Sci, 9500 Euclid Ave, Cleveland, OH 44195 USA;Cleveland Clin Fdn, Dept Hematol & Oncol Res, 9500 Euclid Ave, Cleveland, OH 44195 USA
Dean, Robert M. (author)
Cleveland Clin, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA;Royal Melbourne Hosp City Campus, Melbourne, Vic, Australia
Shaw, Bronwen E. (author)
Med Coll Wisconsin, CIBMTR, Milwaukee, WI 53226 USA
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Brazauskas, Ruta (author)
Med Coll Wisconsin, CIBMTR, Milwaukee, WI 53226 USA;Med Coll Wisconsin, Div Biostat, Milwaukee, WI 53226 USA
Tecca, Heather R. (author)
Med Coll Wisconsin, CIBMTR, Milwaukee, WI 53226 USA
Molenaar, Remco J. (author)
Cleveland Clin Fdn, Dept Quantitat Hlth Sci, 9500 Euclid Ave, Cleveland, OH 44195 USA;Cleveland Clin Fdn, Dept Hematol & Oncol Res, 9500 Euclid Ave, Cleveland, OH 44195 USA;Acad Med Ctr, Dept Med Oncol, Amsterdam, Netherlands
Battiwalla, Minoo (author)
NHLBI, Hematol Branch, Bethesda, MD 20892 USA
Savani, Bipin N. (author)
Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA
Flowers, Mary E. D. (author)
Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA
Cooke, Kenneth R. (author)
Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Pediat Blood & Marrow Transplantat Program, Baltimore, MD USA
Hamilton, Betty K. (author)
Cleveland Clin, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA;Royal Melbourne Hosp City Campus, Melbourne, Vic, Australia
Kalaycio, Matt (author)
Cleveland Clin, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA;Royal Melbourne Hosp City Campus, Melbourne, Vic, Australia
Maciejewski, Jaroslaw P. (author)
Cleveland Clin, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA;Royal Melbourne Hosp City Campus, Melbourne, Vic, Australia
Ahmed, Ibrahim (author)
Childrens Mercy Hosp & Clin, Dept Hematol Oncol & Bone Marrow Transplantat, Kansas City, MO USA
Akpek, Gorgun (author)
Rush Univ, Med Ctr, Stem Cell Transplantat & Cell Therapy, Chicago, IL 60612 USA
Bajel, Ashish (author)
Buchbinder, David (author)
Childrens Hosp Orange Cty, Div Pediat Hematol, Orange, CA 92668 USA
Cahn, Jean-Yves (author)
CHU Grenoble Alpes, Dept Hematol, Grenoble, France
D'Souza, Anita (author)
Med Coll Wisconsin, CIBMTR, Milwaukee, WI 53226 USA
Daly, Andrew (author)
Tom Baker Canc Clin, Calgary, AB, Canada
DeFilipp, Zachariah (author)
Massachusetts Gen Hosp, Blood & Marrow Transplant Program, Boston, MA 02114 USA
Ganguly, Siddhartha (author)
Univ Kansas, Med Ctr, Blood & Marrow Transplantat, Kansas City, KS 66103 USA
Hamadani, Mehdi (author)
Med Coll Wisconsin, CIBMTR, Milwaukee, WI 53226 USA
Hayashi, Robert J. (author)
Washington Univ, Dept Pediat, Sch Med St Louis, St Louis, MO 63130 USA
Hematti, Peiman (author)
Univ Wisconsin Hosp & Clin, Dept Med, Madison, WI 53792 USA
Inamoto, Yoshihiro (author)
Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan
Khera, Nandita (author)
Mayo Clin, Dept Hematol Oncol, Phoenix, AZ USA
Kindwall-Keller, Tamila (author)
Univ Virginia Hlth Syst, Div Hematol Oncol, Charlottesville, VA USA
Landau, Heather (author)
Mem Sloan Kettering Canc Ctr, Div Hematol, Bone Marrow Transplant Serv, 1275 York Ave, New York, NY 10021 USA
Lazarus, Hillard (author)
Case Western Reserve Univ, Seidman Canc Ctr, Cleveland, OH 44106 USA
Majhail, Navneet S. (author)
Cleveland Clin, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA;Royal Melbourne Hosp City Campus, Melbourne, Vic, Australia
Marks, David I. (author)
Univ Hosp Bristol NHS Trust, Adult Bone Marrow Transplant, Bristol, Avon, England
Olsson, Richard F. (author)
Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden
Seo, Sachiko (author)
Natl Canc Res Ctr East, Dept Hematol & Oncol, Chiba, Japan
Steinberg, Amir (author)
Mt Sinai Hosp, Dept Hematol Oncol, New York, NY 10029 USA
William, Basem M. (author)
Ohio State Med Ctr, Columbus, OH USA
Wirk, Baldeep (author)
Seattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA
Yared, Jean A. (author)
Univ Maryland, Dept Med, Baltimore, MD 21201 USA
Aljurf, Mahmoud (author)
King Faisal Specialist Hosp & Res Ctr, Dept Oncol, Riyadh, Saudi Arabia
Abidi, Muneer H. (author)
Wayne State Univ, Karmanos Canc Inst, Dept Oncol, Detroit, MI USA
Allewelt, Heather (author)
Duke Univ, Med Ctr, Durham, NC USA
Beitinjaneh, Amer (author)
Univ Miami, Miami, FL USA
Cook, Rachel (author)
Oregon Hlth & Sci Univ, Portland, OR 97201 USA
Cornell, Robert F. (author)
Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA
Fay, Joseph W. (author)
Baylor Univ, Med Ctr, Dallas, TX USA
Hale, Gregory (author)
Johns Hopkins All Childrens Hosp, Dept Hematol Oncol, St Petersburg, FL USA
Chakrabarty, Jennifer Holter (author)
Univ Oklahoma, Dept Hematol Oncol, Oklahoma City, OK USA
Jodele, Sonata (author)
Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA
Kasow, Kimberly A. (author)
Univ N Carolina, Chapel Hill, NC 27515 USA
Mahindra, Anuj (author)
Scripps Blood & Marrow Transplant Program, La Jolla, CA USA
Malone, Adriana K. (author)
Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA
Popat, Uday (author)
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
Rizzo, J. Douglas (author)
Natl Canc Res Ctr East, Dept Hematol & Oncol, Chiba, Japan
Schouten, Harry C. (author)
Acad Ziekenhuis, Dept Hematol, Maastricht, Netherlands
Warwick, Anne B. (author)
Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA
Wood, William A. (author)
Univ N Carolina, Chapel Hill, NC 27515 USA
Sekeres, Mikkael A. (author)
Cleveland Clin, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA;Royal Melbourne Hosp City Campus, Melbourne, Vic, Australia
Litzow, Mark R. (author)
Mayo Clin, Dept Med, Rochester, MN USA
Gale, Robert P. (author)
Imperial Coll London, Dept Med, London, England
Hashmi, Shahrukh K. (author)
King Faisal Specialist Hosp & Res Ctr, Dept Oncol, Riyadh, Saudi Arabia
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 (creator_code:org_t)
Elsevier BV, 2018
2018
English.
In: Leukemia research. - : Elsevier BV. - 0145-2126 .- 1873-5835. ; 74, s. 130-136
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: Exposures to DNA-damaging drugs and ionizing radiations increase risks of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).Methods: 9028 recipients of hematopoietic cell autotransplants (1995-2010) for Hodgkin lymphoma (HL; n=916), non-Hodgkin lymphoma (NHL; n=3546) and plasma cell myeloma (PCM; n=4566), reported to the CIBMTR, were analyzed for risk of subsequent AML or MDS.Results: 335 MDS/ AML cases were diagnosed posttransplant (3.7%). Variables associated with an increased risk for AML or MDS in multivariate analyses were: (1) conditioning with total body radiation versus chemotherapy alone for HL (HR=4.0; 95% confidence interval [1.4, 11.6]) and NHL (HR=2.5 [1.1, 2.5]); (2) >= 3 versus 1 line of chemotherapy for NHL (HR=1.9 [1.3, 2.8]); and (3) subjects with NHL transplanted in 2005-2010 versus 1995-1999 (HR=2.1 [1.5, 3.1]). Using Surveillance, Epidemiology and End Results (SEER) data, we found risks for AML/ MDS in HL, NHL and PCM to be 5-10 times the background rate. In contrast, relative risks were 10-50 for AML and approximately 100 for MDS in the autotransplant cohort.Conclusions: There are substantial risks of AML and MDS after autotransplants for HL, NHL and PCM.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Keyword

Autotransplant
AML
MDS
CIBMTR
SEER
Therapy-related
New cancers

Publication and Content Type

ref (subject category)
art (subject category)

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