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Circulating microRNA plasma profile in MuSK plus myasthenia gravis

Sabre, Liis (author)
Uppsala universitet,Klinisk neurofysiologi
Guptill, Jeffrey T. (author)
Duke Univ, Dept Neurol, Durham, NC USA
Russo, Melissa (author)
Duke Univ, Dept Neurol, Durham, NC USA
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Juel, Vern C. (author)
Duke Univ, Dept Neurol, Durham, NC USA
Massey, Janice M. (author)
Duke Univ, Dept Neurol, Durham, NC USA
Howard, James F., Jr. (author)
Univ N Carolina, Dept Neurol, Chapel Hill, NC 27515 USA
Hobson-Webb, Lisa D. (author)
Duke Univ, Dept Neurol, Durham, NC USA
Rostedt Punga, Anna (author)
Uppsala universitet,Klinisk neurofysiologi
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 (creator_code:org_t)
Elsevier BV, 2018
2018
English.
In: Journal of Neuroimmunology. - : Elsevier BV. - 0165-5728 .- 1872-8421. ; 325, s. 87-91
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Muscle-specific tyrosine kinase antibody positive myasthenia gravis (MuSK+ MG) is an immunological subtype with distinctive pathogenic mechanisms and clinical features. The aim of this study was to analyze the circulating plasma microRNA profile of patients with MuSK + MG. From the discovery cohort miR-210-3p, miR-3243p and miR-328-3p were further analyzed in the validation cohort. We found a distinct plasma profile of miR210-3p and miR-324-3p that were significantly decreased in MuSK+ MG patients compared to healthy controls (4.1 +/- 1.4 vs 5.1 +/- 1.4, p = .006 and 4.7 +/- 1.0 vs 5.4 +/- 1.3, p = .02). These findings reveal a distinct plasma miRNA profile in MuSK+ MG.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Keyword

Muscle-specific tyrosine kinase
MuSK
Myasthenia gravis
microRNA
Biomarker

Publication and Content Type

ref (subject category)
art (subject category)

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