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Circulating microRN...
Circulating microRNA plasma profile in MuSK plus myasthenia gravis
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- Sabre, Liis (author)
- Uppsala universitet,Klinisk neurofysiologi
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- Guptill, Jeffrey T. (author)
- Duke Univ, Dept Neurol, Durham, NC USA
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- Russo, Melissa (author)
- Duke Univ, Dept Neurol, Durham, NC USA
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- Juel, Vern C. (author)
- Duke Univ, Dept Neurol, Durham, NC USA
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- Massey, Janice M. (author)
- Duke Univ, Dept Neurol, Durham, NC USA
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- Howard, James F., Jr. (author)
- Univ N Carolina, Dept Neurol, Chapel Hill, NC 27515 USA
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- Hobson-Webb, Lisa D. (author)
- Duke Univ, Dept Neurol, Durham, NC USA
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- Rostedt Punga, Anna (author)
- Uppsala universitet,Klinisk neurofysiologi
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Journal of Neuroimmunology. - : Elsevier BV. - 0165-5728 .- 1872-8421. ; 325, s. 87-91
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Muscle-specific tyrosine kinase antibody positive myasthenia gravis (MuSK+ MG) is an immunological subtype with distinctive pathogenic mechanisms and clinical features. The aim of this study was to analyze the circulating plasma microRNA profile of patients with MuSK + MG. From the discovery cohort miR-210-3p, miR-3243p and miR-328-3p were further analyzed in the validation cohort. We found a distinct plasma profile of miR210-3p and miR-324-3p that were significantly decreased in MuSK+ MG patients compared to healthy controls (4.1 +/- 1.4 vs 5.1 +/- 1.4, p = .006 and 4.7 +/- 1.0 vs 5.4 +/- 1.3, p = .02). These findings reveal a distinct plasma miRNA profile in MuSK+ MG.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Muscle-specific tyrosine kinase
- MuSK
- Myasthenia gravis
- microRNA
- Biomarker
Publication and Content Type
- ref (subject category)
- art (subject category)
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