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Sökning: onr:"swepub:oai:DiVA.org:uu-423369" > Associations betwee...

Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project

Jackson, Sarah S. (författare)
Karolinska Institutet
Adami, Hans-Olov (författare)
Karolinska Institutet
Andreotti, Gabriella (författare)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
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Beane-Freeman, Laura E. (författare)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
de Gonzalez, Amy Berrington (författare)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Buring, Julie E. (författare)
Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA USA.
Fraser, Gary E. (författare)
Loma Linda Univ, Sch Publ Hlth, Loma Linda, CA 92350 USA.
Freedman, Neal D. (författare)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Gapstur, Susan M. (författare)
Amer Canc Soc Inc, Behav & Epidemiol Res Grp, Atlanta, GA USA.
Gierach, Gretchen (författare)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Giles, Graham G. (författare)
Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Parkville, Vic, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.
Grodstein, Francine (författare)
Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
Hartge, Patricia (författare)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Jenab, Mazda (författare)
Int Agcy Res Canc IARC WHO, Sect Nutr & Metab, Lyon, France.
Kirsh, Victoria (författare)
Ontario Inst Canc Res, Toronto, ON, Canada.;Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
Knutsen, Synnove F. (författare)
Loma Linda Univ, Sch Publ Hlth, Loma Linda, CA 92350 USA.
Lan, Qing (författare)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Larsson, Susanna C. (författare)
Karolinska Institutet,Uppsala universitet,Ortopedi,Inst Environm Med, Karolinska Inst, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden
Lee, I-Min (författare)
Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA USA.
Lee, Mei-Hsuan (författare)
Natl Yang Ming Univ, Inst Clin Med, Taipei, Taiwan.
Liao, Linda M. (författare)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Milne, Roger L. (författare)
Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Parkville, Vic, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.
Monroe, Kristine R. (författare)
Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA.
Neuhouser, Marian L. (författare)
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Canc Prevent Program, Seattle, WA 98104 USA.
O'Brien, Katie M. (författare)
NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.
Petrick, Jessica L. (författare)
Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA.
Purdue, Mark P. (författare)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Rohan, Thomas E. (författare)
Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
Sandin, Sven (författare)
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
Sandler, Dale P. (författare)
NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.
Sawada, Norie (författare)
Natl Canc Ctr, Ctr Publ Hlth Sci, Epidemiol & Prevent Grp, Tokyo, Japan.
Shadyab, Aladdin H. (författare)
Univ Calif San Diego, Sch Med, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA.
Simon, Tracey G. (författare)
Massachusetts Gen Hosp, Dept Med, Div Gastroenterol, Boston, MA USA.;Massachusetts Gen Hosp & Harvard Med, Clin & Translat Epidemiol Unit, Boston, MA USA.
Sinha, Rashmi (författare)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Stolzenberg-Solomon, Rachael (författare)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Tsugane, Shoichiro (författare)
Natl Canc Ctr, Ctr Publ Hlth Sci, Epidemiol & Prevent Grp, Tokyo, Japan.
Weiderpass, Elisabete (författare)
Int Agcy Res Canc IARC, Lyon, France.
Wolk, Alicja (författare)
Karolinska Institutet,Uppsala universitet,Institutionen för kirurgiska vetenskaper,Inst Environm Med, Karolinska Inst, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden
Yang, Hwai-, I (författare)
Natl Yang Ming Univ, Inst Clin Med, Taipei, Taiwan.;Acad Sinica, Genom Res Ctr, Taipei, Taiwan.
Zheng, Wei (författare)
Vanderbilt Univ, Dept Med, Div Epidemiol, Vanderbilt Epidemiol Ctr, Nashville, TN USA.;Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Nashville, TN 37235 USA.
McGlynn, Katherine A. (författare)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Campbell, Peter T. (författare)
Amer Canc Soc Inc, Behav & Epidemiol Res Grp, Atlanta, GA USA.
Koshiol, Jill (författare)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
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Karolinska Institutet NCI, Div Canc Epidemiol & Genet, Rockville, MD USA (creator_code:org_t)
ELSEVIER, 2020
2020
Engelska.
Ingår i: Journal of Hepatology. - : ELSEVIER. - 0168-8278 .- 1600-0641. ; 73, s. 863-872
Relaterad länk:
https://europepmc.or...
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https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background & Aims: Gallbladder cancer (GBC) is known to have a female predominance while other biliary tract cancers (BTCs) have a male predominance. However, the role of female reproductive factors in BTC etiology remains unclear. Methods: We pooled data from 19 studies of >1.5 million women participating in the Biliary Tract Cancers Pooling Project to examine the associations of parity, age at menarche, reproductive years, and age at menopause with BTC. Associations for age at menarche and reproductive years with BTC were analyzed separately for Asian and non-Asian women. Hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards models, stratified by study. Results: During 21,681,798 person-years of follow-up, 875 cases of GBC, 379 of intrahepatic bile duct cancer (IHBDC), 450 of extrahepatic bile duct cancer (EHBDC), and 261 of ampulla of Vater cancer (AVC) occurred. High parity was associated with risk of GBC (HR >= 5 vs. 0 births 1.72; 95% CI 1.25-2.38). Age at menarche (HR per year increase 1.15; 95% CI 1.06-1.24) was associated with GBC risk in Asian women while reproductive years were associated with GBC risk (HR per 5 years 1.13; 95% CI 1.04-1.22) in non-Asian women. Later age at menarche was associated with IHBDC (HR 1.19; 95% CI 1.09-1.31) and EHBDC (HR 1.11; 95% CI 1.01-1.22) in Asian women only. Conclusion: We observed an increased risk of GBC with increasing parity. Among Asian women, older age at menarche was associated with increased risk for GBC, IHBDC, and EHBDC, while increasing reproductive years was associated with GBC in non-Asian women. These results suggest that sex hormones have distinct effects on cancers across the biliary tract that vary by geography. Lay summary: Our findings show that the risk of gallbladder cancer is increased among women who have given birth (especially women with 5 or more children). In women from Asian countries, later age at menarche increases the risk of gallbladder cancer, intrahepatic bile duct cancer and extrahepatic bile duct cancer. We did not see this same association in women from Western countries. Age at menopause was not associated with the risk of any biliary tract cancers. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

Reproductive factors
Parity
Biliary tract cancer
Gallbladder cancer

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