Gender specific airway gene expression in COPD sub-phenotypes supports a role of mitochondria and of different types of leukocytes

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Gender specific airway gene expression in COPD sub-phenotypes supports a role of mitochondria and of different types of leukocytes

Esteve-Codina, Anna (författare): Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.

Hofer, Thomas P. (författare): Helmholtz Zentrum Muenchen & Asklepios Klin, EvA Study Ctr, Gauting, Germany.;Helmholtz Zentrum Muenchen, Immunoanalyt Core Facil, Munich, Germany.

Burggraf, Dorothe (författare): Helmholtz Zentrum Muenchen & Asklepios Klin, EvA Study Ctr, Gauting, Germany.

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Heiss-Neumann, Marion S. (författare): Helmholtz Zentrum Muenchen & Asklepios Klin, EvA Study Ctr, Gauting, Germany.

Gesierich, Wolfgang (författare): Helmholtz Zentrum Muenchen & Asklepios Klin, EvA Study Ctr, Gauting, Germany.

Boland, Anne (författare): Univ Paris Saclay, CEA, Inst Biol Francois Jacob, Ctr Natl Rech Genom Humaine CNRGH, Evry, France.

Olaso, Robert (författare): Univ Paris Saclay, CEA, Inst Biol Francois Jacob, Ctr Natl Rech Genom Humaine CNRGH, Evry, France.

Bihoreau, Marie-Therese (författare): Univ Paris Saclay, CEA, Inst Biol Francois Jacob, Ctr Natl Rech Genom Humaine CNRGH, Evry, France.

Deleuze, Jean-Francois (författare): Univ Paris Saclay, CEA, Inst Biol Francois Jacob, Ctr Natl Rech Genom Humaine CNRGH, Evry, France.

Moeller, Winfried (författare): Helmholtz Zentrum Muenchen, Inst Lung Biol & Dis, Neuherberg, Germany.

Schmid, Otmar (författare): Helmholtz Zentrum Muenchen, Inst Lung Biol & Dis, Neuherberg, Germany.

Artigas, Maria Soler (författare): Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.

Renner, Kathrin (författare): Univ Hosp Regensburg, Internal Med 3, Regensburg, Germany.

Hohlfeld, Jens M. (författare): Fraunhofer Inst Toxicol & Expt Med, Hannover, Germany.;Hannover Med Sch, Dept Resp Med, Hannover, Germany.;German Ctr Lung Res DZL, Hannover, Germany.

Welte, Tobias (författare): Hannover Med Sch, Dept Resp Med, Hannover, Germany.;German Ctr Lung Res DZL, Hannover, Germany.

Fuehner, Thomas (författare): Hannover Med Sch, Dept Resp Med, Hannover, Germany.;German Ctr Lung Res DZL, Hannover, Germany.

Jerrentrup, Lukas (författare): German Ctr Lung Res DZL, Marburg, Germany.;Philipps Univ, Univ Med Ctr Giessen & Marburg, Dept Med Pulm & Crit Care Med, Marburg, Germany.

Koczulla, Andreas Rembert (författare): German Ctr Lung Res DZL, Marburg, Germany.;Philipps Univ, Univ Med Ctr Giessen & Marburg, Dept Med Pulm & Crit Care Med, Marburg, Germany.

Greulich, Timm (författare): German Ctr Lung Res DZL, Marburg, Germany.;Philipps Univ, Univ Med Ctr Giessen & Marburg, Dept Med Pulm & Crit Care Med, Marburg, Germany.

Prasse, Antje (författare): Fraunhofer Inst Toxicol & Expt Med, Hannover, Germany.;Hannover Med Sch, Dept Resp Med, Hannover, Germany.;German Ctr Lung Res DZL, Hannover, Germany.

Mueller-Quernheim, Joachim (författare): Univ Freiburg, Fac Med, Dept Pneumol, Freiburg, Germany.

Gupta, Sumit (författare): Univ Leicester, NIHR Leicester BRC, Inst Lung Hlth, Leicester, Leics, England.

Brightling, Christopher (författare): Univ Leicester, NIHR Leicester BRC, Inst Lung Hlth, Leicester, Leics, England.

Subramanian, Deepak R. (författare): Univ Hosp Coventry & Warwickshire NHS Trust, Dept Resp Med, Coventry, W Midlands, England.

Parr, David G. (författare): Univ Hosp Coventry & Warwickshire NHS Trust, Dept Resp Med, Coventry, W Midlands, England.

Kolsum, Umme (författare): Univ Manchester, Univ Hosp South Manchester Fdn Trust, Med Evaluat Unit, Manchester, Lancs, England.

Gupta, Vandana (författare): Univ Manchester, Univ Hosp South Manchester Fdn Trust, Med Evaluat Unit, Manchester, Lancs, England.

Barta, Imre (författare): Natl Koranyi Inst TB & Pulmonol, Dept Pathophysiol, Budapest, Hungary.

Dome, Balazs (författare): Natl Koranyi Inst TB & Pulmonol, Dept Tumorbiol, Budapest, Hungary.

Strausz, Janos (författare): Natl Koranyi Inst TB & Pulmonol, Dept Pneumol, Budapest, Hungary.

Stendardo, Mariarita (författare): Univ Ferrara, Dept Med Sci, Ferrara, Italy.;Ferrara City Hosp, Ferrara, Italy.

Piattella, Marco (författare): Univ Ferrara, Dept Med Sci, Ferrara, Italy.;Ferrara City Hosp, Ferrara, Italy.

Boschetto, Piera (författare): Univ Ferrara, Dept Med Sci, Ferrara, Italy.;Ferrara City Hosp, Ferrara, Italy.

Korzybski, Damian (författare): Natl Inst TB & Lung Dis, Dept Resp Med 2, Warsaw, Poland.

Gorecka, Dorota (författare): Natl Inst TB & Lung Dis, Dept Resp Med 2, Warsaw, Poland.

Nowinski, Adam (författare)

Dabad, Marc (författare): Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.

Fernandez-Callejo, Marcos (författare): Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.

Endesfelder, David (författare): Helmholtz Zentrum Muenchen, ICT Dept, Munich, Germany.

zu Castell, Wolfgang (författare): Helmholtz Zentrum Muenchen, Dept Strategy & Digitalizat, Munich, Germany.;Tech Univ Munich, Fac Math, Munich, Germany.

Hiemstra, Pieter S. (författare): Leiden Univ, Dept Pulmonol, Med Ctr, Leiden, Netherlands.

Venge, Per (författare): Uppsala universitet,Klinisk kemi

Noessner, Elfriede (författare): Helmholtz Zentrum Muenchen, Immunoanalyt Tissue Control Immunocytes, Munich, Germany.

Griebel, Thasso (författare): Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.

Heath, Simon (författare): Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.

Singh, Dave (författare): Univ Manchester, Univ Hosp South Manchester Fdn Trust, Med Evaluat Unit, Manchester, Lancs, England.

Gut, Ivo (författare): Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.

Ziegler-Heitbrock, Loems (författare): Helmholtz Zentrum Muenchen & Asklepios Klin, EvA Study Ctr, Gauting, Germany.

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Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain;Univ Pompeu Fabra UPF, Barcelona, Spain. Helmholtz Zentrum Muenchen & Asklepios Klin, EvA Study Ctr, Gauting, Germany.;Helmholtz Zentrum Muenchen, Immunoanalyt Core Facil, Munich, Germany. (creator_code:org_t)

2021-06-18
2021
Engelska.
Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 11:1

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://www.nature.c...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Chronic obstructive pulmonary disease (COPD) is a destructive inflammatory disease and the genes expressed within the lung are crucial to its pathophysiology. We have determined the RNAseq transcriptome of bronchial brush cells from 312 stringently defined ex-smoker patients. Compared to healthy controls there were for males 40 differentially expressed genes (DEGs) and 73 DEGs for females with only 26 genes shared. The gene ontology (GO) term "response to bacterium" was shared, with several different DEGs contributing in males and females. Strongly upregulated genes TCN1 and CYP1B1 were unique to males and females, respectively. For male emphysema (E)-dominant and airway disease (A)-dominant COPD (defined by computed tomography) the term "response to stress" was found for both sub-phenotypes, but this included distinct up-regulated genes for the E-sub-phenotype (neutrophil-related CSF3R, CXCL1, MNDA) and for the A-sub-phenotype (macrophage-related KLF4, F3, CD36). In E-dominant disease, a cluster of mitochondria-encoded (MT) genes forms a signature, able to identify patients with emphysema features in a confirmation cohort. The MT-CO2 gene is upregulated transcriptionally in bronchial epithelial cells with the copy number essentially unchanged. Both MT-CO2 and the neutrophil chemoattractant CXCL1 are induced by reactive oxygen in bronchial epithelial cells. Of the female DEGs unique for E- and A-dominant COPD, 88% were detected in females only. In E-dominant disease we found a pronounced expression of mast cell-associated DEGs TPSB2, TPSAB1 and CPA3. The differential genes discovered in this study point towards involvement of different types of leukocytes in the E- and A-dominant COPD sub-phenotypes in males and females.

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Av författaren/redakt...: Esteve-Codina, A ...; Hofer, Thomas P.; Burggraf, Doroth ...; Heiss-Neumann, M ...; Gesierich, Wolfg ...; Boland, Anne; visa fler...; Olaso, Robert; Bihoreau, Marie- ...; Deleuze, Jean-Fr ...; Moeller, Winfrie ...; Schmid, Otmar; Artigas, Maria S ...; Renner, Kathrin; Hohlfeld, Jens M ...; Welte, Tobias; Fuehner, Thomas; Jerrentrup, Luka ...; Koczulla, Andrea ...; Greulich, Timm; Prasse, Antje; Mueller-Quernhei ...; Gupta, Sumit; Brightling, Chri ...; Subramanian, Dee ...; Parr, David G.; Kolsum, Umme; Gupta, Vandana; Barta, Imre; Dome, Balazs; Strausz, Janos; Stendardo, Maria ...; Piattella, Marco; Boschetto, Piera; Korzybski, Damia ...; Gorecka, Dorota; Nowinski, Adam; Dabad, Marc; Fernandez-Callej ...; Endesfelder, Dav ...; zu Castell, Wolf ...; Hiemstra, Pieter ...; Venge, Per; Noessner, Elfrie ...; Griebel, Thasso; Heath, Simon; Singh, Dave; Gut, Ivo; Ziegler-Heitbroc ...; visa färre...

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Av lärosätet: Uppsala universitet

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Gender specific airway gene expression in COPD sub-phenotypes supports a role of mitochondria and of different types of leukocytes

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