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Prediction of norma...
Prediction of normal-tissue tolerance to radiotherapy from in-vitro cellular radiation sensitivity.
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Burnet, N G (författare)
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- Nyman, Jan, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för onkologi,Institute of Selected Clinical Sciences, Department of Oncology
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Turesson, I (författare)
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visa fler...
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Wurm, R (författare)
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Yarnold, J R (författare)
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Peacock, J H (författare)
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visa färre...
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(creator_code:org_t)
- 1992
- 1992
- Engelska.
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Ingår i: Lancet. - 0140-6736. ; 339:8809, s. 1570-1
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- The success of radiotherapy depends on the total radiation dose, which is limited by the tolerance of surrounding normal tissues. Since there is substantial variation among patients in normal-tissue radiosensitivity, we have tested the hypothesis that in-vitro cellular radiosensitivity is correlated with in-vitro normal-tissue responses. We exposed skin fibroblast cell lines from six radiation-treated patients to various doses of radiation and measured the proportions surviving. There was a strong relation between fibroblast sensitivity in vitro and normal-tissue reactions, especially acute effects. Assessment of radiosensitivity could lead to improved tumour cure rates by enabling radiation doses to be tailored to the individual.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Breast Neoplasms
- radiotherapy
- Cell Survival
- radiation effects
- Cells
- Cultured
- radiation effects
- Dose-Response Relationship
- Radiation
- Fibroblasts
- radiation effects
- Humans
- Predictive Value of Tests
- Radiation Tolerance
- Skin
- radiation effects
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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