SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:gup.ub.gu.se/228909"
 

Search: onr:"swepub:oai:gup.ub.gu.se/228909" > Genome-wide associa...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.

Felix, Janine F (author)
Bradfield, Jonathan P (author)
Monnereau, Claire (author)
show more...
van der Valk, Ralf J P (author)
Stergiakouli, Evie (author)
Chesi, Alessandra (author)
Gaillard, Romy (author)
Feenstra, Bjarke (author)
Thiering, Elisabeth (author)
Kreiner-Møller, Eskil (author)
Mahajan, Anubha (author)
Pitkänen, Niina (author)
Joro, Raimo (author)
Cavadino, Alana (author)
Huikari, Ville (author)
Franks, Steve (author)
Groen-Blokhuis, Maria M (author)
Cousminer, Diana L (author)
Marsh, Julie A (author)
Lehtimäki, Terho (author)
Curtin, John A (author)
Vioque, Jesus (author)
Ahluwalia, Tarunveer S (author)
Myhre, Ronny (author)
Price, Thomas S (author)
Vilor-Tejedor, Natalia (author)
Yengo, Loïc (author)
Grarup, Niels (author)
Ntalla, Ioanna (author)
Ang, Wei (author)
Atalay, Mustafa (author)
Bisgaard, Hans (author)
Blakemore, Alexandra I (author)
Bonnefond, Amelie (author)
Carstensen, Lisbeth (author)
Eriksson, Johan (author)
Flexeder, Claudia (author)
Franke, Lude (author)
Geller, Frank (author)
Geserick, Mandy (author)
Hartikainen, Anna-Liisa (author)
Haworth, Claire M A (author)
Hirschhorn, Joel N (author)
Hofman, Albert (author)
Holm, Jens-Christian (author)
Horikoshi, Momoko (author)
Hottenga, Jouke Jan (author)
Huang, Jinyan (author)
Kadarmideen, Haja N (author)
Kähönen, Mika (author)
Kiess, Wieland (author)
Lakka, Hanna-Maaria (author)
Lakka, Timo A (author)
Lewin, Alexandra M (author)
Liang, Liming (author)
Lyytikäinen, Leo-Pekka (author)
Ma, Baoshan (author)
Magnus, Per (author)
McCormack, Shana E (author)
McMahon, George (author)
Mentch, Frank D (author)
Middeldorp, Christel M (author)
Murray, Clare S (author)
Pahkala, Katja (author)
Pers, Tune H (author)
Pfäffle, Roland (author)
Postma, Dirkje S (author)
Power, Christine (author)
Simpson, Angela (author)
Sengpiel, Verena, 1977 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Tiesler, Carla M T (author)
Torrent, Maties (author)
Uitterlinden, André G (author)
van Meurs, Joyce B (author)
Vinding, Rebecca (author)
Waage, Johannes (author)
Wardle, Jane (author)
Zeggini, Eleftheria (author)
Zemel, Babette S (author)
Dedoussis, George V (author)
Pedersen, Oluf (author)
Froguel, Philippe (author)
Sunyer, Jordi (author)
Plomin, Robert (author)
Jacobsson, Bo, 1960 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Hansen, Torben (author)
Gonzalez, Juan R (author)
Custovic, Adnan (author)
Raitakari, Olli T (author)
Pennell, Craig E (author)
Widén, Elisabeth (author)
Boomsma, Dorret I (author)
Koppelman, Gerard H (author)
Sebert, Sylvain (author)
Järvelin, Marjo-Riitta (author)
Hyppönen, Elina (author)
McCarthy, Mark I (author)
Lindi, Virpi (author)
Harri, Niinikoski (author)
Körner, Antje (author)
Bønnelykke, Klaus (author)
Heinrich, Joachim (author)
Melbye, Mads (author)
Rivadeneira, Fernando (author)
Hakonarson, Hakon (author)
Ring, Susan M (author)
Smith, George Davey (author)
Sørensen, Thorkild I A (author)
Timpson, Nicholas J (author)
Grant, Struan F A (author)
Jaddoe, Vincent W V (author)
show less...
 (creator_code:org_t)
2015-11-24
2016
English.
In: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 25:2, s. 389-403
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discovery phase and 11 873 children from 13 studies in the replication phase. In total, 15 loci reached genome-wide significance (P-value < 5 × 10(-8)) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or childhood obesity. We identified three novel loci: rs13253111 near ELP3, rs8092503 near RAB27B and rs13387838 near ADAM23. Per additional risk allele, body mass index increased 0.04 Standard Deviation Score (SDS) [Standard Error (SE) 0.007], 0.05 SDS (SE 0.008) and 0.14 SDS (SE 0.025), for rs13253111, rs8092503 and rs13387838, respectively. A genetic risk score combining all 15 SNPs showed that each additional average risk allele was associated with a 0.073 SDS (SE 0.011, P-value = 3.12 × 10(-10)) increase in childhood body mass index in a population of 1955 children. This risk score explained 2% of the variance in childhood body mass index. This study highlights the shared genetic background between childhood and adult body mass index and adds three novel loci. These loci likely represent age-related differences in strength of the associations with body mass index.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Find more in SwePub

By the author/editor
Felix, Janine F
Bradfield, Jonat ...
Monnereau, Clair ...
van der Valk, Ra ...
Stergiakouli, Ev ...
Chesi, Alessandr ...
show more...
Gaillard, Romy
Feenstra, Bjarke
Thiering, Elisab ...
Kreiner-Møller, ...
Mahajan, Anubha
Pitkänen, Niina
Joro, Raimo
Cavadino, Alana
Huikari, Ville
Franks, Steve
Groen-Blokhuis, ...
Cousminer, Diana ...
Marsh, Julie A
Lehtimäki, Terho
Curtin, John A
Vioque, Jesus
Ahluwalia, Tarun ...
Myhre, Ronny
Price, Thomas S
Vilor-Tejedor, N ...
Yengo, Loïc
Grarup, Niels
Ntalla, Ioanna
Ang, Wei
Atalay, Mustafa
Bisgaard, Hans
Blakemore, Alexa ...
Bonnefond, Ameli ...
Carstensen, Lisb ...
Eriksson, Johan
Flexeder, Claudi ...
Franke, Lude
Geller, Frank
Geserick, Mandy
Hartikainen, Ann ...
Haworth, Claire ...
Hirschhorn, Joel ...
Hofman, Albert
Holm, Jens-Chris ...
Horikoshi, Momok ...
Hottenga, Jouke ...
Huang, Jinyan
Kadarmideen, Haj ...
Kähönen, Mika
Kiess, Wieland
Lakka, Hanna-Maa ...
Lakka, Timo A
Lewin, Alexandra ...
Liang, Liming
Lyytikäinen, Leo ...
Ma, Baoshan
Magnus, Per
McCormack, Shana ...
McMahon, George
Mentch, Frank D
Middeldorp, Chri ...
Murray, Clare S
Pahkala, Katja
Pers, Tune H
Pfäffle, Roland
Postma, Dirkje S
Power, Christine
Simpson, Angela
Sengpiel, Verena ...
Tiesler, Carla M ...
Torrent, Maties
Uitterlinden, An ...
van Meurs, Joyce ...
Vinding, Rebecca
Waage, Johannes
Wardle, Jane
Zeggini, Elefthe ...
Zemel, Babette S
Dedoussis, Georg ...
Pedersen, Oluf
Froguel, Philipp ...
Sunyer, Jordi
Plomin, Robert
Jacobsson, Bo, 1 ...
Hansen, Torben
Gonzalez, Juan R
Custovic, Adnan
Raitakari, Olli ...
Pennell, Craig E
Widén, Elisabeth
Boomsma, Dorret ...
Koppelman, Gerar ...
Sebert, Sylvain
Järvelin, Marjo- ...
Hyppönen, Elina
McCarthy, Mark I
Lindi, Virpi
Harri, Niinikosk ...
Körner, Antje
Bønnelykke, Klau ...
Heinrich, Joachi ...
Melbye, Mads
Rivadeneira, Fer ...
Hakonarson, Hako ...
Ring, Susan M
Smith, George Da ...
Sørensen, Thorki ...
Timpson, Nichola ...
Grant, Struan F ...
Jaddoe, Vincent ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Clinical Laborat ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Obstetrics Gynae ...
Articles in the publication
Human molecular ...
By the university
University of Gothenburg

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view