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Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer

Stevens, Kristen N. (author)
Vachon, Celine M. (author)
Lee, Adam M. (author)
show more...
Slager, Susan (author)
Karolinska Institutet
Lesnick, Timothy (author)
Olswold, Curtis (author)
Fasching, Peter A. (author)
Miron, Penelope (author)
Eccles, Diana (author)
Carpenter, Jane E. (author)
Godwin, Andrew K. (author)
Ambrosone, Christine (author)
Winqvist, Robert (author)
Brauch, Hiltrud (author)
Schmidt, Marjanka K. (author)
Cox, Angela (author)
Cross, Simon S. (author)
Sawyer, Elinor (author)
Hartmann, Arndt (author)
Beckmann, Matthias W. (author)
Schulz-Wendtland, Ruediger (author)
Ekici, Arif B. (author)
Tapper, William J. (author)
Gerty, Susan M. (author)
Durcan, Lorraine (author)
Graham, Nikki (author)
Hein, Rebecca (author)
Nickels, Stephan (author)
Flesch-Janys, Dieter (author)
Heinz, Judith (author)
Sinn, Hans-Peter (author)
Konstantopoulou, Irene (author)
Fostira, Florentia (author)
Pectasides, Dimitrios (author)
Dimopoulos, Athanasios M. (author)
Fountzilas, George (author)
Clarke, Christine L. (author)
Balleine, Rosemary (author)
Olson, Janet E. (author)
Fredericksen, Zachary (author)
Diasio, Robert B. (author)
Pathak, Harsh (author)
Ross, Eric (author)
Weaver, JoEllen (author)
Ruediger, Thomas (author)
Försti, Asta (author)
Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
Duennebier, Thomas (author)
Ademuyiwa, Foluso (author)
Kulkarni, Swati (author)
Pylkaes, Katri (author)
Jukkola-Vuorinen, Arja (author)
Ko, Yon-Dschun (author)
Van Limbergen, Erik (author)
Janssen, Hilde (author)
Peto, Julian (author)
Fletcher, Olivia (author)
Giles, Graham G. (author)
Baglietto, Laura (author)
Verhoef, Senno (author)
Tomlinson, Ian (author)
Kosma, Veli-Matti (author)
Beesley, Jonathan (author)
Greco, Dario (author)
Blomqvist, Carl (author)
Irwanto, Astrid (author)
Liu, Jianjun (author)
Blows, Fiona M. (author)
Dawson, Sarah-Jane (author)
Margolin, Sara (author)
Mannermaa, Arto (author)
Martin, Nicholas G. (author)
Montgomery, Grant W. (author)
Lambrechts, Diether (author)
Silva, Isabel dos Santos (author)
Severi, Gianluca (author)
Hamann, Ute (author)
Pharoah, Paul (author)
Easton, Douglas F. (author)
Chang-Claude, Jenny (author)
Yannoukakos, Drakoulis (author)
Nevanlinna, Heli (author)
Wang, Xianshu (author)
Couch, Fergus J. (author)
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 (creator_code:org_t)
2011
2011
English.
In: Cancer Research. - 1538-7445. ; 71:19, s. 6240-6249
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer. Cancer Res; 71(19); 6240-9. (C)2011 AACR.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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By the author/editor
Stevens, Kristen ...
Vachon, Celine M ...
Lee, Adam M.
Slager, Susan
Lesnick, Timothy
Olswold, Curtis
show more...
Fasching, Peter ...
Miron, Penelope
Eccles, Diana
Carpenter, Jane ...
Godwin, Andrew K ...
Ambrosone, Chris ...
Winqvist, Robert
Brauch, Hiltrud
Schmidt, Marjank ...
Cox, Angela
Cross, Simon S.
Sawyer, Elinor
Hartmann, Arndt
Beckmann, Matthi ...
Schulz-Wendtland ...
Ekici, Arif B.
Tapper, William ...
Gerty, Susan M.
Durcan, Lorraine
Graham, Nikki
Hein, Rebecca
Nickels, Stephan
Flesch-Janys, Di ...
Heinz, Judith
Sinn, Hans-Peter
Konstantopoulou, ...
Fostira, Florent ...
Pectasides, Dimi ...
Dimopoulos, Atha ...
Fountzilas, Geor ...
Clarke, Christin ...
Balleine, Rosema ...
Olson, Janet E.
Fredericksen, Za ...
Diasio, Robert B ...
Pathak, Harsh
Ross, Eric
Weaver, JoEllen
Ruediger, Thomas
Försti, Asta
Duennebier, Thom ...
Ademuyiwa, Folus ...
Kulkarni, Swati
Pylkaes, Katri
Jukkola-Vuorinen ...
Ko, Yon-Dschun
Van Limbergen, E ...
Janssen, Hilde
Peto, Julian
Fletcher, Olivia
Giles, Graham G.
Baglietto, Laura
Verhoef, Senno
Tomlinson, Ian
Kosma, Veli-Matt ...
Beesley, Jonatha ...
Greco, Dario
Blomqvist, Carl
Irwanto, Astrid
Liu, Jianjun
Blows, Fiona M.
Dawson, Sarah-Ja ...
Margolin, Sara
Mannermaa, Arto
Martin, Nicholas ...
Montgomery, Gran ...
Lambrechts, Diet ...
Silva, Isabel do ...
Severi, Gianluca
Hamann, Ute
Pharoah, Paul
Easton, Douglas ...
Chang-Claude, Je ...
Yannoukakos, Dra ...
Nevanlinna, Heli
Wang, Xianshu
Couch, Fergus J.
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Public Health Gl ...
Articles in the publication
Cancer Research
By the university
Lund University
Karolinska Institutet

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