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Dynamics of Cell Ge...
Dynamics of Cell Generation and Turnover in the Human Heart.
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- Bergmann, Olaf (author)
- Karolinska Institutet
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Zdunek, Sofia (author)
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Felker, Anastasia (author)
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- Salehpour, Mehran (author)
- Uppsala universitet,Tillämpad kärnfysik
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- Alkass, Kanar (author)
- Karolinska Institutet
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Bernard, Samuel (author)
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Sjostrom, Staffan L (author)
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Szewczykowska, Mirosława (author)
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Jackowska, Teresa (author)
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Dos Remedios, Cris (author)
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- Malm, Torsten (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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Andrä, Michaela (author)
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Jashari, Ramadan (author)
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Nyengaard, Jens R (author)
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- Possnert, Göran (author)
- Uppsala universitet,Institutionen för fysik och astronomi
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- Jovinge, Stefan (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Druid, Henrik (author)
- Karolinska Institutet
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- Frisén, Jonas (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 161:7, s. 1566-1575
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http://dx.doi.org/10...
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Abstract
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- The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived (14)C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart. VIDEO ABSTRACT.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Cell
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To the university's database
- By the author/editor
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Bergmann, Olaf
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Zdunek, Sofia
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Felker, Anastasi ...
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Salehpour, Mehra ...
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Alkass, Kanar
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Bernard, Samuel
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show more...
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Sjostrom, Staffa ...
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Szewczykowska, M ...
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Jackowska, Teres ...
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Dos Remedios, Cr ...
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Malm, Torsten
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Andrä, Michaela
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Jashari, Ramadan
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Nyengaard, Jens ...
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Possnert, Göran
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Jovinge, Stefan
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Druid, Henrik
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Frisén, Jonas
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
- Articles in the publication
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Cell
- By the university
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Lund University
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Uppsala University
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Karolinska Institutet