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Immune gene express...
Immune gene expression and response to chemotherapy in advanced breast cancer
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- Foukakis, Theodoros (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Lövrot, John (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Matikas, Alexios (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Zerdes, Ioannis (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Lorent, Julie (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Tobin, Nick (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Suzuki, Chikako (författare)
- Karolinska Institutet,Karolinska Institute
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- Brage, Suzanne Egyházi (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Carlsson, Lena (författare)
- Sundsvall Hospital
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- Einbeigi, Zakaria (författare)
- Sahlgrenska University Hospital
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- Linderholm, Barbro (författare)
- Karolinska Institutet,Sahlgrenska University Hospital,Karolinska University Hospital
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- Loman, Niklas (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröstcancer-genetik,Institutionen för kliniska vetenskaper, Lund,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Breastcancer-genetics,Department of Clinical Sciences, Lund,Skåne University Hospital
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- Malmberg, Martin (författare)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Helsingborg Hospital
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- Fernö, Mårten (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Individuell Bröstcancerbehandling,Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Personalized Breast Cancer Treatment,Lund University Research Groups,Skåne University Hospital
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- Skoog, Lambert (författare)
- Karolinska University Hospital
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- Bergh, Jonas (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Hatschek, Thomas (författare)
- Karolinska Institutet,Karolinska University Hospital
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(creator_code:org_t)
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- 2018-01-25
- 2018
- Engelska.
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 118:4, s. 480-488
- Relaterad länk:
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http://dx.doi.org/10...
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background:Transcriptomic profiles have shown promise as predictors of response to neoadjuvant chemotherapy in breast cancer (BC). This study aimed to explore their predictive value in the advanced BC (ABC) setting.Methods:In a Phase 3 trial of first-line chemotherapy in ABC, a fine needle aspiration biopsy (FNAB) was obtained at baseline. Intrinsic molecular subtypes and gene modules related to immune response, proliferation, oestrogen receptor (ER) signalling and recurring genetic alterations were analysed for association with objective response to chemotherapy. Gene-set enrichment analysis (GSEA) of responders vs non-responders was performed independently. Lymphocytes were enumerated in FNAB smears and the absolute abundance of immune cell types was calculated using the Microenvironment Cell Populations counter method.Results:Gene expression data were available for 109 patients. Objective response to chemotherapy was statistically significantly associated with an immune module score (odds ratio (OR)=1.62; 95% confidence interval (CI), 1.03-2.64; P=0.04). Subgroup analysis showed that this association was restricted to patients with ER-positive or luminal tumours (OR=3.54; 95%, 1.43-10.86; P=0.012 and P for interaction=0.04). Gene-set enrichment analysis confirmed that in these subgroups, immune-related gene sets were enriched in responders.Conclusions:Immune-related transcriptional signatures may predict response to chemotherapy in ER-positive and luminal ABC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Foukakis, Theodo ...
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Lövrot, John
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Matikas, Alexios
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Zerdes, Ioannis
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Lorent, Julie
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Tobin, Nick
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visa fler...
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Suzuki, Chikako
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Brage, Suzanne E ...
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Carlsson, Lena
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Einbeigi, Zakari ...
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Linderholm, Barb ...
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Loman, Niklas
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Malmberg, Martin
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Fernö, Mårten
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Skoog, Lambert
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Bergh, Jonas
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Hatschek, Thomas
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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British Journal ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet