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Nonandrogenic anabo...
Nonandrogenic anabolic hormones predict risk of frailty : European male ageing study prospective data
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- Swiecicka, Agnieszka (författare)
- University of Manchester
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- Lunt, Mark (författare)
- University of Manchester
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- Ahern, Tomás (författare)
- University of Manchester
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- O'Neill, Terence W. (författare)
- National Health Service Trust, NHS England,University of Manchester
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- Bartfai, György (författare)
- University of Szeged
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- Casanueva, Felipe (författare)
- CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN)
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- Forti, Gianni (författare)
- University of Florence
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- Giwercman, Aleksander (författare)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
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- Han, Thang S (författare)
- Royal Holloway University of London
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- Lean, Michael E J (författare)
- University of Glasgow
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- Pendleton, Neil (författare)
- University of Manchester
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- Punab, Margus (författare)
- Tartu University Hospital
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- Slowikowska-Hilczer, Jolanta (författare)
- Medical University of Lodz
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- Vanderschueren, Dirk (författare)
- Catholic University of Leuven
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- Huhtaniemi, Ilpo T. (författare)
- University of Turku,Imperial College London
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- Wu, Frederick C W (författare)
- University of Manchester
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- Rutter, Martin K. (författare)
- Great Ormond Street Hospital,University of Manchester
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(creator_code:org_t)
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- 2017-05-09
- 2017
- Engelska 9 s.
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 102:8, s. 2798-2806
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://academic.oup...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Context: Low levels of nonandrogenic anabolic hormones have been linked with frailty, but evidence is conflicting and prospective data are largely lacking. Objective: To determine associations between nonandrogenic anabolic hormones and prospective changes in frailty status. Design/Setting: A 4.3-year prospective observational study of community-dwelling men participating in the European Male Ageing Study. Participants: Men (n = 3369) aged 40 to 79 years from eight European centers. Main Outcome Measures: Frailty status was determined using frailty phenotype (FP; n = 2114) and frailty index (FI; n = 2444). Analysis: Regression models assessed relationships between baseline levels of insulinlike growth factor 1 (IGF-1), its binding protein 3 (IGFBP-3), dehydroepiandrosterone sulfate (DHEA-S), 25-hydroxyvitamin D (25OHD), and parathyroid hormone (PTH), with changes in frailty status (worsening or improving frailty). Results: The risk of worsening FP and FI decreased with 1 standard deviation higher IGF-1, IGFBP-3, and 25OHD in models adjusted for age, body mass index, center, and baseline frailty [IGF-1: odds ratio (OR) for worsening FP, 0.82 (0.73, 0.93), percentage change in FI, -3.7% (-6.0, -1.5); IGFBP-3: 0.84 (0.75, 0.95), -4.2% (-6.4, -2.0); 25OHD: 0.84 (0.75, 0.95); -4.4%, (-6.7, -2.0)]. Relationships between IGF-1 and FI were attenuated after adjusting for IGFBP-3. Higher DHEA-S was associated with a lower risk of worsening FP only in men >70 years old [OR, 0.57 (0.35, 0.92)]. PTH was unrelated to change in frailty status. Conclusions: These longitudinal data confirm the associations between nonandrogenic anabolic hormones and the changes in frailty status. Interventional studies are needed to establish causality and determine therapeutic implications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
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Swiecicka, Agnie ...
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Lunt, Mark
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Ahern, Tomás
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O'Neill, Terence ...
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Bartfai, György
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Casanueva, Felip ...
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visa fler...
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Forti, Gianni
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Giwercman, Aleks ...
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Han, Thang S
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Lean, Michael E ...
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Pendleton, Neil
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Punab, Margus
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Slowikowska-Hilc ...
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Vanderschueren, ...
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Huhtaniemi, Ilpo ...
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Wu, Frederick C ...
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Rutter, Martin K ...
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