Sökning: onr:"swepub:oai:lup.lub.lu.se:d6cb0f0d-9f0d-4abd-9b45-fc05b997f481" >
Gastrointestinal mi...
Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury
-
- Kapur, Rick (författare)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Trombocyt immunologi,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Platelet Immunology,Lund University Research Groups
-
- Kim, Michael (författare)
- Saint Michael's Hospital
-
- Rebetz, Johan (författare)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Trombocyt immunologi,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Platelet Immunology,Lund University Research Groups
-
visa fler...
-
- Hallström, Björn (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine
-
- Björkman, Jonas T (författare)
- Skåne University Hospital
-
- Takabe-French, Alisa (författare)
- Saint Michael's Hospital
-
- Kim, Noel (författare)
- Saint Michael's Hospital
-
- Liu, Jonathan (författare)
- Saint Michael's Hospital
-
- Shanmugabhavananthan, Shanjeevan (författare)
- Saint Michael's Hospital
-
- Milosevic, Stefan (författare)
- Saint Michael's Hospital
-
- McVey, Mark J (författare)
- Canadian Blood Services,University of Toronto
-
- Speck, Edwin R (författare)
- Saint Michael's Hospital
-
- Semple, John W (författare)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Trombocyt immunologi,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups,Platelet Immunology,Saint Michael's Hospital,University of Toronto,Canadian Blood Services
-
visa färre...
-
(creator_code:org_t)
- 2018-07-10
- 2018
- Engelska.
-
Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 2:13, s. 1651-1663
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://ashpublicati...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Transfusion-related acute lung injury (TRALI) is a syndrome of respiratory distress upon blood transfusion and is the leading cause of transfusion-related fatalities. Whether the gut microbiota plays any role in the development of TRALI is currently unknown. We observed that untreated barrier-free (BF) mice suffered from severe antibody-mediated acute lung injury, whereas the more sterile housed specific pathogen-free (SPF) mice and gut flora-depleted BF mice were both protected from lung injury. The prevention of TRALI in the SPF mice and gut flora-depleted BF mice was associated with decreased plasma macrophage inflammatory protein-2 levels as well as decreased pulmonary neutrophil accumulation. DNA sequencing of amplicons of the 16S ribosomal RNA gene revealed a varying gastrointestinal bacterial composition between BF and SPF mice. BF fecal matter transferred into SPF mice significantly restored TRALI susceptibility in SPF mice. These data reveal a link between the gut flora composition and the development of antibody-mediated TRALI in mice. Assessment of gut microbial composition may help in TRALI risk assessment before transfusion.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Kapur, Rick
-
Kim, Michael
-
Rebetz, Johan
-
Hallström, Björn
-
Björkman, Jonas ...
-
Takabe-French, A ...
-
visa fler...
-
Kim, Noel
-
Liu, Jonathan
-
Shanmugabhavanan ...
-
Milosevic, Stefa ...
-
McVey, Mark J
-
Speck, Edwin R
-
Semple, John W
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
- Artiklar i publikationen
-
Blood Advances
- Av lärosätet
-
Lunds universitet