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miR-126 Regulates D...
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.
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Lechman, Eric R (author)
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Gentner, Bernhard (author)
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Ng, Stanley W K (author)
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Schoof, Erwin M (author)
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van Galen, Peter (author)
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Kennedy, James A (author)
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Nucera, Silvia (author)
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Ciceri, Fabio (author)
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Kaufmann, Kerstin B (author)
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Takayama, Naoya (author)
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Dobson, Stephanie M (author)
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Trotman-Grant, Aaron (author)
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Krivdova, Gabriela (author)
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Elzinga, Janneke (author)
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Mitchell, Amanda (author)
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- Nilsson, Björn (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
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Hermans, Karin G (author)
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Eppert, Kolja (author)
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Marke, Rene (author)
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Isserlin, Ruth (author)
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Voisin, Veronique (author)
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Bader, Gary D (author)
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Zandstra, Peter W (author)
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Golub, Todd R (author)
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Ebert, Benjamin L (author)
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Lu, Jun (author)
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Minden, Mark (author)
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Wang, Jean C Y (author)
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Naldini, Luigi (author)
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Dick, John E (author)
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Cancer Cell. - : Elsevier BV. - 1878-3686 .- 1535-6108. ; 29:2, s. 214-228
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
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- To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we generated a prognostic LSC-associated miRNA signature derived from functionally validated subpopulations of AML samples. For one signature miRNA, miR-126, high bioactivity aggregated all in vivo patient sample LSC activity into a single sorted population, tightly coupling miR-126 expression to LSC function. Through functional studies, miR-126 was found to restrain cell cycle progression, prevent differentiation, and increase self-renewal of primary LSC in vivo. Compared with prior results showing miR-126 regulation of normal hematopoietic stem cell (HSC) cycling, these functional stem effects are opposite between LSC and HSC. Combined transcriptome and proteome analysis demonstrates that miR-126 targets the PI3K/AKT/MTOR signaling pathway, preserving LSC quiescence and promoting chemotherapy resistance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Lechman, Eric R
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Gentner, Bernhar ...
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Ng, Stanley W K
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Schoof, Erwin M
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van Galen, Peter
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Kennedy, James A
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show more...
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Nucera, Silvia
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Ciceri, Fabio
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Kaufmann, Kersti ...
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Takayama, Naoya
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Dobson, Stephani ...
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Trotman-Grant, A ...
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Krivdova, Gabrie ...
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Elzinga, Janneke
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Mitchell, Amanda
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Nilsson, Björn
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Hermans, Karin G
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Eppert, Kolja
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Marke, Rene
-
Isserlin, Ruth
-
Voisin, Veroniqu ...
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Bader, Gary D
-
Zandstra, Peter ...
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Golub, Todd R
-
Ebert, Benjamin ...
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Lu, Jun
-
Minden, Mark
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Wang, Jean C Y
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Naldini, Luigi
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Dick, John E
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Cell
- By the university
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Lund University