Sökning: onr:"swepub:oai:lup.lub.lu.se:f0c2b346-a12a-47f0-827f-2c468074e178" >
Adult-onset type 1 ...
Adult-onset type 1 diabetic patients with less severe clinical manifestation have less risk DR-DQ genotypes than childhood-onset patients
-
- Ren, Wenqian (författare)
- Third Affiliated Hospital of Sun Yat‐sen University
-
- Yang, Daizhi (författare)
- Third Affiliated Hospital of Sun Yat‐sen University
-
- Jiang, Ziyu (författare)
- Third Affiliated Hospital of Sun Yat‐sen University
-
visa fler...
-
- Xian, Yingxin (författare)
- Third Affiliated Hospital of Sun Yat‐sen University
-
- Huang, Qianwen (författare)
- Third Affiliated Hospital of Sun Yat‐sen University
-
- Luo, Sihui (författare)
- University of Science and Technology of China,Third Affiliated Hospital of Sun Yat‐sen University
-
- Zheng, Xueying (författare)
- University of Science and Technology of China
-
- Yan, Jinhua (författare)
- Third Affiliated Hospital of Sun Yat‐sen University
-
- Xu, Wen (författare)
- Third Affiliated Hospital of Sun Yat‐sen University
-
- Yao, Bin (författare)
- Third Affiliated Hospital of Sun Yat‐sen University
-
- Wang, Cong Yi (författare)
- Huazhong University of Science and Technology
-
- Bei, Jin Xin (författare)
- Sun Yat-sen University
-
- Groop, Leif (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Science and Technology of China,Skåne University Hospital
-
- Noble, Janelle A. (författare)
- Children's Hospital Oakland Research Institute
-
- Weng, Jianping (författare)
- University of Science and Technology of China,Third Affiliated Hospital of Sun Yat‐sen University
-
visa färre...
-
(creator_code:org_t)
- 2020-06-21
- 2021
- Engelska.
-
Ingår i: Diabetes/Metabolism Research and Reviews. - : Wiley. - 1520-7552 .- 1520-7560. ; 37:1
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: The aim of this study was to investigate differences in clinical features and HLA genotypes between adult-onset and childhood-onset patients with type 1 diabetes in a Chinese population. Materials and Methods: This study enrolled 716 Han Chinese patients with type 1 diabetes from Guangdong (258 childhood-onset and 458 adult-onset) to compare their clinical features. Of them 214 patients with classical type 1 diabetes (100 childhood-onset and 114 adult-onset) were selected for HLA DR and DQ genotyping by next-generation sequencing. Results: Adult-onset patients were characterized by longer duration of symptoms before diagnosis, lower frequency of DKA at disease onset, less frequent autoantibody positivity, higher serum C-peptide concentrations, and better glycemic control. These findings were replicated in the restricted cohort of 214 patients with classical type 1 diabetes. Compared with childhood-onset patients, adult-onset patients had a lower frequency of the DR9 haplotype, as well as lower frequency of high-risk DR3/DR4 and DR3/DR9 genotypes, but higher frequency of DR3/DR3 genotype and DR3/X, DR4/X or DR9/X (X, non-risk) genotypes. Conclusions: Adult-onset type 1 diabetic patients with susceptible haplotypes (DR3, DR4 or DR9) were more likely to carry protective DR-DQ haplotypes than childhood-onset patients, which suggested the association between less risk DR-DQ genotypes and the less severe clinical manifestation in adult-onset patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- adult onset diabetes
- age of diabetes onset
- clinical characteristics
- genetics
- HLA typing
- type 1 diabetes
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Ren, Wenqian
-
Yang, Daizhi
-
Jiang, Ziyu
-
Xian, Yingxin
-
Huang, Qianwen
-
Luo, Sihui
-
visa fler...
-
Zheng, Xueying
-
Yan, Jinhua
-
Xu, Wen
-
Yao, Bin
-
Wang, Cong Yi
-
Bei, Jin Xin
-
Groop, Leif
-
Noble, Janelle A ...
-
Weng, Jianping
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Diabetes/Metabol ...
- Av lärosätet
-
Lunds universitet