Association of changes in inflammation with variation in glycaemia, insulin resistance and secretion based on the KORA study

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Association of changes in inflammation with variation in glycaemia, insulin resistance and secretion based on the KORA study

de las Heras Gala, Tonia (författare): German Center for Diabetes Research,Helmholtz Zentrum München

Herder, Christian (författare): German Center for Diabetes Research,Heinrich Heine University Düsseldorf

Rutters, Femke (författare): Amsterdam UMC - Vrije Universiteit Amsterdam

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Carstensen-Kirberg, Maren (författare): German Center for Diabetes Research,Heinrich Heine University Düsseldorf

Huth, Cornelia (författare): Helmholtz Zentrum München,German Center for Diabetes Research

Stehouwer, Coen D.A. (författare): Maastricht University Medical Centre

Nijpels, Giel (författare): Amsterdam UMC - Vrije Universiteit Amsterdam

Schalkwijk, Casper (författare): Maastricht University Medical Centre

Flyvbjerg, Allan (författare): Steno Diabetes Center Copenhagen

Franks, Paul W. (författare): Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups

Dekker, Jacqueline (författare): Amsterdam UMC - Vrije Universiteit Amsterdam

Meisinger, Christa (författare): Ludwig-Maximilian University of Munich,German Center for Diabetes Research,Helmholtz Zentrum München

Koenig, Wolfgang (författare): German Centre for Cardiovascular Research,University of Ulm,Technical University of Munich

Roden, Michael (författare): Heinrich Heine University Düsseldorf,German Center for Diabetes Research

Rathmann, Wolfgang (författare): Heinrich Heine University Düsseldorf,German Center for Diabetes Research

Peters, Annette (författare): German Center for Diabetes Research,Helmholtz Zentrum München,German Centre for Cardiovascular Research

Thorand, Barbara (författare): Helmholtz Zentrum München,German Center for Diabetes Research

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(creator_code:org_t)

2018-10-02
2018
Engelska.
Ingår i: Diabetes/Metabolism Research and Reviews. - : Wiley. - 1520-7552. ; 34:8

Relaterad länk:: http://dx.doi.org/10...; visa fler...; https://lup.lub.lu.s...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Aims: Subclinical systemic inflammation may contribute to the development of type 2 diabetes, but its association with early progression of glycaemic deterioration in persons without diabetes has not been fully investigated. Our primary aim was to assess longitudinal associations of changes in pro-inflammatory (leukocytes, high-sensitivity C-reactive protein (hsCRP)) and anti-inflammatory (adiponectin) markers with changes in markers that assessed glycaemia, insulin resistance, and secretion (HbA1c, HOMA-IR, and HOMA-ß). Furthermore, we aimed to directly compare longitudinal with cross-sectional associations. Materials and methods: This study includes 819 initially nondiabetic individuals with repeated measurements from the Cooperative Health Research in the Region of Augsburg (KORA) S4/F4 cohort study (median follow-up: 7.1 years). Longitudinal and cross-sectional associations were simultaneously examined using linear mixed growth models. Changes in markers of inflammation were used as independent and changes in markers of glycaemia/insulin resistance/insulin secretion as dependent variables. Models were adjusted for age, sex, major lifestyle and metabolic risk factors for diabetes using time-varying variables in the final model. Results: Changes of leukocyte count were positively associated with changes in HbA1c and HOMA-ß while changes in adiponectin were inversely associated with changes in HbA1c. All examined cross-sectional associations were statistically significant; they were generally stronger and mostly directionally consistent to the longitudinal association estimates. Conclusions: Adverse changes in low-grade systemic inflammation go along with glycaemic deterioration and increased insulin secretion independently of changes in other risk factors, suggesting that low-grade inflammation may contribute to the development of hyperglycaemia and a compensatory increase in insulin secretion.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

glycaemic deterioration
HbA
inflammation
insulin resistance
ß-cell function

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Diabetes/Metabolism Research and Reviews (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: de las Heras Gal ...; Herder, Christia ...; Rutters, Femke; Carstensen-Kirbe ...; Huth, Cornelia; Stehouwer, Coen ...; visa fler...; Nijpels, Giel; Schalkwijk, Casp ...; Flyvbjerg, Allan; Franks, Paul W.; Dekker, Jacqueli ...; Meisinger, Chris ...; Koenig, Wolfgang; Roden, Michael; Rathmann, Wolfga ...; Peters, Annette; Thorand, Barbara; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

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