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Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

Rietveld, CA (author)
Erasmus University (NL)
Esko, T (author)
University of Tartu
Davies, G (author)
Bristol University (GB),University of Edinburgh
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Pers, TH (author)
Erasmus University (NL),Boston Children's Hospital
Turley, P (author)
Massachusetts General Hospital (US)
Benyamin, B (author)
Cornell University (US),University of Queensland (AU)
Chabris, CF (author)
Union College (US),Erasmus Medical Center
Emilsson, V (author)
University of Iceland,University of Queensland (AU)
Johnson, AD (author)
National Heart Institute
Lee, JJ (author)
University of Minnesota Twin Cities (US),Erasmus Medical Center
de Leeuw, C (author)
University of Amsterdam (NL)
Marioni, RE (author)
University of Queensland (AU)
Medland, SE (author)
Queensland Institute of Medical Research
Miller, MB (author)
University of Minnesota Twin Cities (US)
Rostapshova, O (author)
Harvard University (US)
van der Lee, SJ (author)
Vinkhuyzen, AAE (author)
Amin, N (author)
Erasmus Medical Center
Conley, D (author)
Massachusetts Institute of Technology (US),University of Edinburgh
Derringer, J (author)
University of Illinois (US)
van Duijn, CM (author)
Leiden University
Fehrmann, R (author)
University of Groningen (NL)
Franke, L (author)
University of Groningen (NL)
Glaeser, EL (author)
Harvard University (US)
Hansell, NK (author)
QIMR Berghofer Medical Research Institute
Hayward, C (author)
University of Edinburgh
Iacono, WG (author)
University of Minnesota Twin Cities (US)
Ibrahim-Verbaas, C (author)
Harvard University (US)
Jaddoe, V (author)
Erasmus Medical Center
Karjalainen, J (author)
University of Groningen (NL)
Laibson, D (author)
Harvard University (US)
Lichtenstein, P (author)
Karolinska Institutet,Karolinska Institutet (SE)
Liewald, DC (author)
Massachusetts Institute of Technology (US)
Magnusson, PKE (author)
Karolinska Institutet,Karolinska Institutet (SE)
Martin, NG (author)
Queensland Institute of Medical Research
Mcgue, M (author)
University of Edinburgh,University of Queensland (AU)
McMahon, G (author)
Bristol University (GB)
Pedersen, NL (author)
Karolinska Institutet
Pinker, S (author)
University of Cambridge
Porteous, DJ (author)
University of Edinburgh
Posthuma, D (author)
VU University (NL)
Rivadeneira, F (author)
Erasmus University (NL)
Smith, BH (author)
University of Dundee
Johannesson, Magnus (author)
Stockholm School of Economics,Handelshögskolan i Stockholm
Tiemeier, H (author)
Timpson, NJ (author)
Bristol University (GB)
Trzaskowski, M (author)
King's College London (GB)
Uitterlinden, AG (author)
Erasmus University (NL)
Verhulst, FC (author)
Ward, ME (author)
Bristol University (GB)
Wright, MJ (author)
QIMR Berghofer Medical Research Institute
Smith, GD (author)
Deary, IJ (author)
University of Edinburgh
Johannesson, M (author)
Plomin, R (author)
King's College London (GB)
Visscher, PM (author)
Benjamin, DJ (author)
Cesarini, D (author)
Koellinger, PD (author)
Erasmus School of Economics (NL)
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 (creator_code:org_t)
2014-09-08
2014
English.
In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490 .- 0027-8424. ; 111:38, s. 13790-13794
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • We identify several common genetic variants associated with cognitive performance using a two-stage approach: we conduct a genome-wide association study of educational attainment to generate a set of candidates, and then we estimate the association of these variants with cognitive performance. In older Americans, we find that these variants are jointly associated with cognitive health. Bioinformatics analyses implicate a set of genes that is associated with a particular neurotransmitter pathway involved in synaptic plasticity, the main cellular mechanism for learning and memory. In addition to the substantive contribution, this work also serves to show a proxy-phenotype approach to discovering common genetic variants that is likely to be useful for many phenotypes of interest to social scientists (such as personality traits).

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

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art (subject category)

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