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Sökning: onr:"22081512" > Insights into the e...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004763naa a22007933a 4500
00122081512
003SE-LIBR
00520171207154131.0
007cr||||||||||||
008171207s2013 sw |||| o |||| ||eng c
0247 a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1970692 uri
0247 a urn:nbn:se:uu:diva-1970692 urn
0247 a 10.1186/1471-2164-14-952 doi
040 a S
0410 a eng
042 9 EPLK
1001 a Rands, Chris M.4 aut
2451 0a Insights into the evolution of Darwin's finches from comparative analysis of the Geospiza magnirostris genome sequenceh [Elektronisk resurs]
260 c 2013
500 a Published
5060 a gratis
520 a Background: A classical example of repeated speciation coupled with ecological diversification is the evolution of 14 closely related species of Darwin's (Galapagos) finches (Thraupidae, Passeriformes). Their adaptive radiation in the Galapagos archipelago took place in the last 2-3 million years and some of the molecular mechanisms that led to their diversification are now being elucidated. Here we report evolutionary analyses of genome of the large ground finch, Geospiza magnirostris. Results: 13,291 protein-coding genes were predicted from a 991.0 Mb G. magnirostris genome assembly. We then defined gene orthology relationships and constructed whole genome alignments between the G. magnirostris and other vertebrate genomes. We estimate that 15% of genomic sequence is functionally constrained between G. magnirostris and zebra finch. Genic evolutionary rate comparisons indicate that similar selective pressures acted along the G. magnirostris and zebra finch lineages suggesting that historical effective population size values have been similar in both lineages. 21 otherwise highly conserved genes were identified that each show evidence for positive selection on amino acid changes in the Darwin's finch lineage. Two of these genes (Igf2r and Pou1f1) have been implicated in beak morphology changes in Darwin's finches. Five of 47 genes showing evidence of positive selection in early passerine evolution have cilia related functions, and may be examples of adaptively evolving reproductive proteins. Conclusions: These results provide insights into past evolutionary processes that have shaped G. magnirostris genes and its genome, and provide the necessary foundation upon which to build population genomics resources that will shed light on more contemporaneous adaptive and non-adaptive processes that have contributed to the evolution of the Darwin's finches.
650 7a Natural Sciences2 hsv
650 7a Naturvetenskap2 hsv0 264446
653 0a Genomics
653 0a Evolution
653 0a Darwin's finches
653 0a Large ground finch
653 0a Geospiza magnirostris
7001 a Darling, Aaron4 aut
7001 a Fujita, Matthew4 aut
7001 a Kong, Lesheng4 aut
7001 a Webster, Matthew T.4 aut
7001 a Clabaut, Celine4 aut
7001 a Emes, Richard D.4 aut
7001 a Heger, Andreas4 aut
7001 a Meader, Stephen4 aut
7001 a Hawkins, Michael Brent4 aut
7001 a Eisen, Michael B.4 aut
7001 a Teiling, Clotilde4 aut
7001 a Affourtit, Jason4 aut
7001 a Boese, Benjamin4 aut
7001 a Grant, Peter R.4 aut
7001 a Grant, Barbara Rosemary4 aut
7001 a Eisen, Jonathan A.4 aut
7001 a Abzhanov, Arhat4 aut
7001 a Ponting, Chris P.4 aut
7101 2a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
7101 2a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 pbl
7721 8i channel recordw 19753896
7730 8i Värdpublikationt BMC Genomicsg 14, 95x 1471-2164
8564 0u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-197069
8564 0u http://dx.doi.org/10.1186/1471-2164-14-95
8564 0u http://uu.diva-portal.org/smash/get/diva2:611618/FULLTEXT01
950 k6 650a Atomerw hu Naturvetenskap
950 k6 650a Experimentw hu Naturvetenskap
950 k6 650a Fysikw hu Naturvetenskap
950 k6 650a Kemiw hu Naturvetenskap
950 k6 650a Kloningw hu Naturvetenskap
950 k6 650a Laboratorierw hu Naturvetenskap
950 k6 650a Marinbiologiw hu Naturvetenskap
950 k6 650a Matematikw hu Naturvetenskap
950 k6 650a Medicinska experimentw hu Naturvetenskap
950 k6 650a Tyngdlagenw hu Naturvetenskap
950 k6 650a Utvecklingsläraw hu Naturvetenskap
841 5 APISa x ab 171210||0000|||||001||||||000000e 1
0247 5 APISa urn:nbn:se:uu:diva-1970692 urn
852 5 APISb APIS
8564 05 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-197069

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