onr:"22514136"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03877naa a22006493a 4500 | |
| 001 | 22514136 | |
| 003 | SE-LIBR | |
| 005 | 20180318101741.0 | |
| 007 | cr|||||||||||| | |
| 008 | 180318s2017 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3188402 uri |
| 024 | 7 | a urn:nbn:se:uu:diva-3188402 urn |
| 024 | 7 | a 10.3390/ph100100302 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Fani, Melpomeni4 aut |
| 245 | 1 0 | a Current Status of Radiopharmaceuticals for the Theranostics of Neuroendocrine Neoplasmsh [Elektronisk resurs] |
| 260 | c 2017 | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a Nuclear medicine plays a pivotal role in the management of patients affected by neuroendocrine neoplasms (NENs). Radiolabeled somatostatin receptor analogs are by far the most advanced radiopharmaceuticals for diagnosis and therapy (radiotheranostics) of NENs. Their clinical success emerged receptor-targeted radiolabeled peptides as an important class of radiopharmaceuticals and it paved the way for the investigation of other radioligand-receptor systems. Besides the somatostatin receptors (sstr), other receptors have also been linked to NENs and quite a number of potential radiolabeled peptides have been derived from them. The Glucagon-Like Peptide-1 Receptor (GLP-1R) is highly expressed in benign insulinomas, the Cholecystokinin 2 (CCK2)/Gastrin receptor is expressed in different NENs, in particular medullary thyroid cancer, and the Glucose-dependent Insulinotropic Polypeptide (GIP) receptor was found to be expressed in gastrointestinal and bronchial NENs, where interestingly, it is present in most of the sstr-negative and GLP-1R-negative NENs. Also in the field of sstr targeting new discoveries brought into light an alternative approach with the use of radiolabeled somatostatin receptor antagonists, instead of the clinically used agonists. The purpose of this review is to present the current status and the most innovative strategies for the diagnosis and treatment (theranostics) of neuroendocrine neoplasms using a cadre of radiolabeled regulatory peptides targeting their receptors. | |
| 650 | 7 | a Natural Sciences2 hsv |
| 650 | 7 | a Naturvetenskap2 hsv0 264446 |
| 653 | 0 | a CCK2 |
| 653 | 0 | a GIP |
| 653 | 0 | a GLP-1R |
| 653 | 0 | a exendin-4 |
| 653 | 0 | a gastrin |
| 653 | 0 | a neuroendocrine neoplasms |
| 653 | 0 | a radiolabeled peptides |
| 653 | 0 | a somatostatin receptor antagonists |
| 653 | 0 | a theranostics |
| 700 | 1 | a Peitl, Petra Kolenc4 aut |
| 700 | 1 | a Velikyan, Irinad 1966-4 aut0 263415 |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 772 | 1 8 | i channel recordw 19753896 |
| 773 | 0 8 | i Värdpublikationt Pharmaceuticalsg 10:1x 1424-8247 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318840 |
| 856 | 4 0 | u http://dx.doi.org/10.3390/ph10010030 |
| 856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:1085898/FULLTEXT01 |
| 950 | k | 6 650a Atomerw hu Naturvetenskap |
| 950 | k | 6 650a Experimentw hu Naturvetenskap |
| 950 | k | 6 650a Fysikw hu Naturvetenskap |
| 950 | k | 6 650a Kemiw hu Naturvetenskap |
| 950 | k | 6 650a Kloningw hu Naturvetenskap |
| 950 | k | 6 650a Laboratorierw hu Naturvetenskap |
| 950 | k | 6 650a Marinbiologiw hu Naturvetenskap |
| 950 | k | 6 650a Matematikw hu Naturvetenskap |
| 950 | k | 6 650a Medicinska experimentw hu Naturvetenskap |
| 950 | k | 6 650a Tyngdlagenw hu Naturvetenskap |
| 950 | k | 6 650a Utvecklingsläraw hu Naturvetenskap |
| 841 | 5 APISa x ab 180318||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:uu:diva-3188402 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318840 |
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