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Sökning: onr:"swepub:oai:DiVA.org:liu-170189" > Distribution of his...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004357naa a2200469 4500
001oai:DiVA.org:liu-170189
003SwePub
008201001s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1701892 URI
0247 a https://doi.org/10.1007/s00384-020-03747-z2 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Fiehn, Anne-Marie Kanstrupu Zealand Univ Hosp, Denmark; Univ Copenhagen, Denmark4 aut
2451 0a Distribution of histopathological features along the colon in microscopic colitis
264 c 2020-09-12
264 1b Springer,c 2021
338 a print2 rdacarrier
520 a Purpose The diagnosis microscopic colitis (MC) consisting of collagenous colitis (CC) and lymphocytic colitis (LC) relies on histological assessment of mucosal biopsies from the colon. The optimal biopsy strategy for reliable diagnosis of MC is controversial. The aim of this study was to evaluate the distribution of histopathological features of MC throughout the colon. Methods Mucosal biopsies from multiple colonic segments of patients with MC who participated in one of the three prospective European multicenter trials were analyzed. Histological slides were stained with hematoxylin-and-eosin, a connective tissue stain, and CD3 in selected cases. Results In total, 255 patients were included, 199 and 56 patients with CC and LC, respectively. Both groups exhibited a gradient with more pronounced inflammation in the lamina propria in the proximal colon compared with the distal colon. Similarly, the thickness of the subepithelial collagenous band in CC showed a gradient with higher values in the proximal colon. The mean number of intraepithelial lymphocytes was > 20 in all colonic segments in patients within both subgroups. Biopsies from 86 to 94% of individual segments were diagnostic, rectum excluded. Biopsies from non-diagnostic segments often showed features of another subgroup of MC. Conclusion Conclusively, although the severity of the histological changes in MC differed in the colonic mucosa, the minimum criteria required for the diagnosis were present in the random biopsies from the majority of segments. Thus, our findings show MC to be a pancolitis, rectum excluded, questioning previously proclaimed patchiness throughout the colon.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
653 a Colonic biopsies; Histopathology; Histology; Diagnosis; Chronic diarrhea; Inflammatory bowel disease; Microscopic colitis
7001 a Miehlke, Stephanu Univ Hosp Eppendorf, Germany; Univ Hosp Eppendorf, Germany4 aut
7001 a Aust, Danielau Univ Hosp Dresden, Germany4 aut
7001 a Vieth, Michaelu Klinikum Bayreuth, Germany4 aut
7001 a Bonderup, Oleu Silkeborg Hosp, Denmark4 aut
7001 a Fernandez-Banares, Fernandou Hosp Univ Mutua Terrassa, Spain; Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain4 aut
7001 a Mihaly, Emeseu Semmelweis Univ, Hungary4 aut
7001 a Kupcinskas, Juozasu Lithuanian Univ Hlth Sci, Lithuania4 aut
7001 a Madisch, Ahmedu CRH Clin Siloah, Germany4 aut
7001 a Munck, Lars Kristianu Univ Copenhagen, Denmark; Zealand Univ Hosp, Denmark4 aut
7001 a Nacak, Tanjuu Dr Falk Pharma GmbH, Germany4 aut
7001 a Mohrbacher, Ralfu Dr Falk Pharma GmbH, Germany4 aut
7001 a Mueller, Ralphu Dr Falk Pharma GmbH, Germany4 aut
7001 a Greinwald, Rolandu Dr Falk Pharma GmbH, Germany4 aut
7001 a Münch, Andreasu Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken4 aut0 (Swepub:liu)andsa76
7102 a Zealand Univ Hosp, Denmark; Univ Copenhagen, Denmarkb Univ Hosp Eppendorf, Germany; Univ Hosp Eppendorf, Germany4 org
7730 t International Journal of Colorectal Diseased : Springerg 36, s. 151-159q 36<151-159x 0179-1958x 1432-1262
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-170189
8564 8u https://doi.org/10.1007/s00384-020-03747-z

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