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Sökning: onr:"swepub:oai:DiVA.org:oru-18701" > Association of gene...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04490naa a2200721 4500 | |
| 001 | oai:DiVA.org:oru-18701 | |
| 003 | SwePub | |
| 008 | 110929s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-187012 URI |
| 024 | 7 | a https://doi.org/10.2337/db10-15752 DOI |
| 040 | a (SwePub)oru | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Barker, Adam4 aut |
| 245 | 1 0 | a Association of genetic loci with glucose levels in childhood and adolescence a meta-analysis of over 6,000 children |
| 264 | c 2011-05-21 | |
| 264 | 1 | b American Diabetes Association,c 2011 |
| 338 | a print2 rdacarrier | |
| 520 | a OBJECTIVE-To investigate whether associations of common genetic variants recently identified for fasting glucose or insulin levels in nondiabetic adults are detectable in healthy children and adolescents. RESEARCH DESIGN AND METHODS-A total of 16 single nucleotide polymorphisms (SNPs) associated with fasting glucose were genotyped in six studies of children and adolescents of European origin, including over 6,000 boys and girls aged 9-16 years. We performed meta-analyses to test associations of individual SNPs and a weighted risk score of the 16 loci with fasting glucose. RESULTS-Nine loci were associated with glucose levels in healthy children and adolescents, with four of these associations reported in previous studies and five reported here for the first time (GLIS3, PROX1, SLC2A2, ADCY5, and CRY2). Effect sizes were similar to those in adults, suggesting age-independent effects of these fasting glucose loci. Children and adolescents carrying glucose-raising alleles of G6PC2, MTNR1B, GCK, and GLIS3 also showed reduced p-cell function, as indicated by homeostasis model assessment of beta-cell function. Analysis using a weighted risk score showed an increase [beta (95% CI)] in fasting glucose level of 0.026 mrnol/L (0.021-0.031) for each unit increase in the score. CONCLUSIONS-Novel fasting glucose loci identified in genome-wide association studies of adults are associated with altered fasting glucose levels in healthy children and adolescents with effect sizes comparable to adults. In nondiabetic adults, fasting glucose changes little over time, and our results suggest that age-independent effects of fasting glucose loci contribute to long-term interindividual differences in glucose levels from childhood onwards. Diabetes 60:1805-1812, 2011 | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Idrottsvetenskap0 (SwePub)303082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Sport and Fitness Sciences0 (SwePub)303082 hsv//eng |
| 653 | a Sports Science | |
| 653 | a Idrottsvetenskap | |
| 700 | 1 | a Sharp, Stephen J.4 aut |
| 700 | 1 | a Timpson, Nicholas J.4 aut |
| 700 | 1 | a Bouatia-Naji, Nabila4 aut |
| 700 | 1 | a Warrington, Nicole M.4 aut |
| 700 | 1 | a Kanoni, Stavroula4 aut |
| 700 | 1 | a Beilin, Lawrence J.4 aut |
| 700 | 1 | a Brage, Soren4 aut |
| 700 | 1 | a Deloukas, Panos4 aut |
| 700 | 1 | a Evans, David M.4 aut |
| 700 | 1 | a Grontved, Anders4 aut |
| 700 | 1 | a Hassanali, Neelam4 aut |
| 700 | 1 | a Lawlor, Deborah A.4 aut |
| 700 | 1 | a Lecoeur, Cecile4 aut |
| 700 | 1 | a Loos, Ruth J. F.4 aut |
| 700 | 1 | a Lye, Stephen J.4 aut |
| 700 | 1 | a McCarthy, Mark I.4 aut |
| 700 | 1 | a Mori, Trevor A.4 aut |
| 700 | 1 | a Ndiaye, Ndeye Coumba4 aut |
| 700 | 1 | a Newnham, John P.4 aut |
| 700 | 1 | a Ntalla, Ioanna4 aut |
| 700 | 1 | a Pennell, Craig E.4 aut |
| 700 | 1 | a St Pourcain, Beate4 aut |
| 700 | 1 | a Prokopenko, Inga4 aut |
| 700 | 1 | a Ring, Susan M.4 aut |
| 700 | 1 | a Sattar, Naveed4 aut |
| 700 | 1 | a Visvikis-Siest, Sophie4 aut |
| 700 | 1 | a Dedoussis, George V.4 aut |
| 700 | 1 | a Pahner, Lyle J.4 aut |
| 700 | 1 | a Froguel, Philippe4 aut |
| 700 | 1 | a Smith, George Davey4 aut |
| 700 | 1 | a Ekelund, Ulfu Örebro universitet,Hälsoakademin4 aut0 (Swepub:oru)ued |
| 700 | 1 | a Wareham, Nicholas J.4 aut |
| 700 | 1 | a Langenberg, Claudia4 aut |
| 710 | 2 | a Örebro universitetb Hälsoakademin4 org |
| 773 | 0 | t Diabetesd : American Diabetes Associationg 60:6, s. 1805-1812q 60:6<1805-1812x 0012-1797x 1939-327X |
| 856 | 4 | u http://diabetes.diabetesjournals.org/content/60/6/1805.full.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-18701 |
| 856 | 4 8 | u https://doi.org/10.2337/db10-1575 |
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