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Sökning: onr:"swepub:oai:DiVA.org:oru-48982" > Molecular epidemiol...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04623naa a2200577 4500 | |
| 001 | oai:DiVA.org:oru-48982 | |
| 003 | SwePub | |
| 008 | 160306s2002 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:1955048 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-489822 URI |
| 024 | 7 | a https://doi.org/10.1093/carcin/23.5.8092 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19550482 URI |
| 040 | a (SwePub)orud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Hemminki, K.u Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden4 aut |
| 245 | 1 0 | a Molecular epidemiology of VHL gene mutations in renal cell carcinoma patients :b relation to dietary and other factors |
| 264 | 1 | a Oxford, United Kingdom :b Oxford University Press,c 2002 |
| 338 | a print2 rdacarrier | |
| 520 | a Carcinogenic chemicals act through DNA damage and mitogenic effects. No established mechanism explains the cancer preventive effects, if any, of food items, such as vegetables and fruit. If such data were available, preferably on tumor-initiating genes, the evidence for the protective effects would become stronger. The von Hipple-Lindau (VHL) gene is the tumor suppressor gene predisposing to both sporadic renal cell carcinoma (RCC) and von Hippel-Lindau disease. We have earlier analyzed VHL mutations in RCCs from 102 Swedish patients identified in a case-control study and here examine associations between patient characteristics, including dietary habits and mutations, considering the type of mutation. The results are given as odds ratios (OR), separately for smokers and all patients. In univariate analysis, consumption of vegetables and citrus fruit decreased the frequency of VHL mutations among smokers and citrus fruit among all patients. In multivariate analysis of smokers' characteristics, welding fumes showed a risk of 5.63 for multiple VHL mutations. In smokers, citrus fruit decreased the OR of GC to AT mutations to 0.13 and that of multiple mutations to 0.17; vegetables decreased the OR for single mutations to 0.22. Among all subjects, welding fumes were a risk factor and citrus fruit a protective factor. Additionally, an intake of selenium protected against multiple mutations. The present results provide evidence that the intake of vegetables, selenium and particularly of citrus fruit protects the renal VHL gene from mutational insults that may be endogenous or common in a population. Even though most of the associations are biologically plausible, and vegetables and fruit were an a priori hypothesis, fortuitous results cannot be ruled out in this relatively small study. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a Adult | |
| 653 | a Aged | |
| 653 | a Carcinoma | |
| 653 | a Renal Cell/epidemiology/*genetics | |
| 653 | a Humans | |
| 653 | a Kidney Neoplasms/epidemiology/*genetics | |
| 653 | a Ligases/*genetics | |
| 653 | a Male | |
| 653 | a Middle Aged | |
| 653 | a *Molecular Epidemiology | |
| 653 | a *Mutation | |
| 653 | a *Tumor Suppressor Proteins | |
| 653 | a *Ubiquitin-Protein Ligases | |
| 653 | a Von Hippel-Lindau Tumor Suppressor Protein | |
| 653 | a von Hippel-Lindau Disease/*genetics | |
| 700 | 1 | a Jiang, Y.u Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden4 aut |
| 700 | 1 | a Ma, X.u Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden4 aut |
| 700 | 1 | a Yang, K.u Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden4 aut |
| 700 | 1 | a Egevad, L.u Karolinska Institutet4 aut |
| 700 | 1 | a Lindblad, Per,d 1953-u Department of Urology, Sundsvall Hospital, Sundsvall, Sweden4 aut0 (Swepub:oru)pld |
| 710 | 2 | a Karolinska Institutetb Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden4 org |
| 773 | 0 | t Carcinogenesisd Oxford, United Kingdom : Oxford University Pressg 23:5, s. 809-815q 23:5<809-815x 0143-3334x 1460-2180 |
| 856 | 4 | u https://doi.org/10.1093/carcin/23.5.809y Fulltext |
| 856 | 4 | u https://academic.oup.com/carcin/article-pdf/23/5/809/8104437/0230809.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-48982 |
| 856 | 4 8 | u https://doi.org/10.1093/carcin/23.5.809 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1955048 |
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