onr:"swepub:oai:DiVA.org:oru-56331"
Sökning: onr:"swepub:oai:DiVA.org:oru-56331" > Prognostic impact o...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03855naa a2200373 4500 | |
| 001 | oai:DiVA.org:oru-56331 | |
| 003 | SwePub | |
| 008 | 170314s2014 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-563312 URI |
| 024 | 7 | a https://doi.org/10.1016/j.ygyno.2014.08.0262 DOI |
| 040 | a (SwePub)oru | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bohr Mordhorst, Louise,d 1958-u Region Örebro län,Department of Oncology, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)lbt |
| 245 | 1 0 | a Prognostic impact of the expression of Hedgehog proteins in cervical carcinoma FIGO stages I-IV treated with radiotherapy or chemoradiotherapy |
| 264 | 1 | b Academic Press,c 2014 |
| 338 | a print2 rdacarrier | |
| 500 | a Funding Agencies:Research Foundation at the Department of OncologyResearch Funds of the University Hospital, ÖrebroFoundation for Research in Gynecological Cancer, Örebro, Sweden | |
| 520 | a Objective: Hedgehog signaling proteins were assessed in patients with cervical carcinoma receiving chemoradiation. Associations between five Hedgehog proteins and prognosis were studied.Methods: In all, 131 cases of cervical carcinomas (FIGO stages I-IV) were immunohistochemically (IHC) analyzed for Patched (PTCH), Smoothened (SMO), and GLI1, GLI2 and GLI3 protein expression. Associations between Hedgehog protein expressions, clinicopathological factors, and clinical outcome data were examined.Results: Positive IHC staining for the five Hedgehog proteins was recorded in 8% to 37% of the tumor cells. The highest frequency was noted for SMO and the lowest for all. There was a significant association between low SMO- and GLI2-expression and KRAS-mutation. Tumors with overexpressed SMO had a higher frequency of residual tumor or local recurrences than tumors with low SMO expression. Patients with tumors expressing PTCH in more than 75% of the cells had significantly (P = 0.023) better recurrence-free survival than patients with tumors with low expression. The opposite situation was true for SMO. For GLI2, there was a statistically significant difference with regard to overall (P = 0.004) and distant (P = 0.015) relapse rate for groups with expression of GLI2 in the range of 5-25% compared to higher rates.Conclusions: A predictive and prognostic value was found for PTCH, SMO, and GLI2 with regard to residual carcinoma, local recurrences, and for GLI2 distant relapses. The Hedgehog signaling pathway also seems to play an important role in cervical carcinogenesis together with HPV16-infection and KRAS-mutation. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
| 653 | a Cervical carcinoma | |
| 653 | a Hedgehog proteins | |
| 653 | a Prognosis | |
| 700 | 1 | a Ahlin, Ceciliau Department of Oncology, Örebro University Hospital, Örebro, Sweden4 aut |
| 700 | 1 | a Sorbe, Bengt,d 1947-u Region Örebro län,Department of Oncology, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)bse |
| 710 | 2 | a Region Örebro länb Department of Oncology, Örebro University Hospital, Örebro, Sweden4 org |
| 773 | 0 | t Gynecologic Oncologyd : Academic Pressg 135:2, s. 305-311q 135:2<305-311x 0090-8258x 1095-6859 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56331 |
| 856 | 4 8 | u https://doi.org/10.1016/j.ygyno.2014.08.026 |
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