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Sökning: onr:"swepub:oai:DiVA.org:oru-74225" > Gastric Bypass Surg...

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FältnamnIndikatorerMetadata
00005058naa a2200541 4500
001oai:DiVA.org:oru-74225
003SwePub
008190509s2019 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-161608
009oai:prod.swepub.kib.ki.se:141260413
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-742252 URI
0247 a https://doi.org/10.1097/SLA.00000000000029832 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1616082 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1412604132 URI
040 a (SwePub)orud (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Backman, Olofu Umeå universitet,Handkirurgi,Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden4 aut
2451 0a Gastric Bypass Surgery Reduces De Novo Cases of Type 2 Diabetes to Population Levels :b A Nationwide Cohort Study From Sweden
264 1b Lippincott Williams & Wilkins,c 2019
338 a print2 rdacarrier
500 a Funding Agency:National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health  R01DK105948
520 a OBJECTIVE: The aim of this study was to determine long-term changes in pharmacological treatment of type 2 diabetes after primary Roux-en-Y gastric bypass (RYGB) surgery, in patients with and without pharmacological treatment of diabetes preoperatively.SUMMARY OF BACKGROUND DATA: Several studies have shown that gastric bypass has good effect on diabetes, at least in the short-term. This study is a nationwide cohort study using Swedish registers, with basically no patients lost to follow-up during up to 7 years after surgery.METHODS: The effect of RYGB on type 2 diabetes drug treatment was evaluated in this nationwide matched cohort study. Participants were 22,047 adults with BMI ≥30 identified in the nationwide Scandinavian Surgical Obesity Registry, who underwent primary RYGB between 2007 and 2012. For each individual, up to 10 general population comparators were matched on birth year, sex, and place of residence. Prescription data were retrieved from the nationwide Swedish Prescribed Drug Register through September 2015. Incident use of pharmacological treatment was analyzed using Cox regression.RESULTS: Sixty-seven percent of patients with pharmacological treatment of type 2 diabetes before surgery were not using diabetes drugs 2 years after surgery and 61% of patients were not pharmacologically treated up to 7 years after surgery. In patients not using diabetes drugs at baseline, there were 189 new cases of pharmacological treatment of type 2 diabetes in the surgery group and 2319 in the matched general population comparators during a median follow-up of 4.6 years (incidence: 21.4 vs 27.9 per 10,000 person-years; adjusted hazard ratio 0.77, 95% confidence interval 0.67-0.89; P < 0.001).CONCLUSIONS: Gastric bypass surgery not only induces remission of pharmacological treatment of type 2 diabetes but also protects from new onset of pharmacological diabetes treatment. The effect seems to persist in most, but not all, patients over 7 years of follow-up.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
653 a diabetes
653 a diabetes prevention
653 a diabetes remission
653 a diabetes treatment
653 a gastric bypass
7001 a Bruze, Gustafu Karolinska Institutet4 aut
7001 a Näslund, Ingmaru Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden4 aut
7001 a Ottosson, Johan,d 1957-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery4 aut0 (Swepub:oru)jhon
7001 a Marsk, Richardu Karolinska Institutet4 aut
7001 a Neovius, Martinu Karolinska Institutet4 aut
7001 a Näslund, Eriku Karolinska Institutet4 aut
7102 a Umeå universitetb Handkirurgi4 org
7730 t Annals of Surgeryd : Lippincott Williams & Wilkinsg 269:5, s. 895-902q 269:5<895-902x 0003-4932x 1528-1140
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-74225
8564 8u https://doi.org/10.1097/SLA.0000000000002983
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161608
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:141260413

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