Sökning: onr:"swepub:oai:DiVA.org:su-137595" > Fourth Generation o...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03784naa a2200505 4500 | |
001 | oai:DiVA.org:su-137595 | |
003 | SwePub | |
008 | 170109s2016 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-313615 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1375952 URI |
024 | 7 | a https://doi.org/10.1002/humu.230512 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3136152 URI |
040 | a (SwePub)sud (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a for2 swepub-publicationtype |
100 | 1 | a Ke, Rongqin4 aut |
245 | 1 0 | a Fourth Generation of Next-Generation Sequencing Technologies :b Promise and Consequences |
264 | c 2016-08-10 | |
264 | 1 | b Hindawi Limited,c 2016 |
338 | a print2 rdacarrier | |
520 | a In this review, we discuss the emergence of the fourth-generation sequencing technologies that preserve the spatial coordinates of RNA and DNA sequences with up to subcellular resolution, thus enabling back mapping of sequencing reads to the original histological context. This information is used, for example, in two current large-scale projects that aim to unravel the function of the brain. Also in cancer research, fourth-generation sequencing has the potential to revolutionize the field. Cancer Research UK has named Mapping the molecular and cellular tumor microenvironment in order to define new targets for therapy and prognosis one of the grand challenges in tumor biology. We discuss the advantages of sequencing nucleic acids directly in fixed cells over traditional next-generation sequencing (NGS) methods, the limitations and challenges that these new methods have to face to become broadly applicable, and the impact that the information generated by the combination of in situ sequencing and NGS methods will have in research and diagnostics. | |
650 | 7 | a NATURVETENSKAPx Data- och informationsvetenskapx Bioinformatik0 (SwePub)102032 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Computer and Information Sciencesx Bioinformatics0 (SwePub)102032 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a next-generation sequencing | |
653 | a in situ sequencing | |
653 | a single cell sequencing | |
653 | a spatial gene expression | |
653 | a multiplex in situ RNA detection | |
653 | a Datoriserad bildbehandling | |
700 | 1 | a Mignardi, Marcou Uppsala universitet,Avdelningen för visuell information och interaktion,Bildanalys och människa-datorinteraktion4 aut0 (Swepub:uu)marmi748 |
700 | 1 | a Hauling, Thomasu Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)4 aut0 (Swepub:su)thha3442 |
700 | 1 | a Nilsson, Matsu Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)4 aut0 (Swepub:su)matsn |
710 | 2 | a Uppsala universitetb Avdelningen för visuell information och interaktion4 org |
773 | 0 | t Human Mutationd : Hindawi Limitedg 37:12, s. 1363-1367q 37:12<1363-1367x 1059-7794x 1098-1004 |
856 | 4 | u https://doi.org/10.1002/humu.23051y Fulltext |
856 | 4 | u https://doi.org/10.1002/humu.23051 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-137595 |
856 | 4 8 | u https://doi.org/10.1002/humu.23051 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-313615 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy