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Sökning: onr:"swepub:oai:DiVA.org:su-142621" > Lifetime alcohol in...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004143naa a2200541 4500
001oai:DiVA.org:su-142621
003SwePub
008170522s2017 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1426212 URI
0247 a https://doi.org/10.1002/ijc.305682 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Jayasekara, Harindra4 aut
2451 0a Lifetime alcohol intake is associated with an increased risk of KRAS plus and BRAF-/KRAS- but not BRAF plus colorectal cancer
264 c 2016-12-26
264 1b Wiley,c 2017
338 a print2 rdacarrier
520 a Ethanol in alcoholic beverages is a causative agent for colorectal cancer. Colorectal cancer is a biologically heterogeneous disease, and molecular subtypes defined by the presence of somatic mutations in BRAF and KRAS are known to exist. We examined associations between lifetime alcohol intake and molecular and anatomic subtypes of colorectal cancer. We calculated usual alcohol intake for 10-year periods from age 20 using recalled frequency and quantity of beverage-specific consumption for 38,149 participants aged 40-69 years from the Melbourne Collaborative Cohort Study. Cox regression was performed to derive hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between lifetime alcohol intake and colorectal cancer risk. Heterogeneity in the HRs across subtypes of colorectal cancer was assessed. A positive dose-dependent association between lifetime alcohol intake and overall colorectal cancer risk (mean follow-up=14.6 years; n=596 colon and n=326 rectal cancer) was observed (HR=1.08, 95% CI: 1.04-1.12 per 10 g/day increment). The risk was greater for rectal than colon cancer (p(homogeneity)=0.02). Alcohol intake was associated with increased risks of KRAS+ (HR=1.07, 95% CI: 1.00-1.15) and BRAF-/KRAS- (HR=1.05, 95% CI: 1.00-1.11) but not BRAF+ tumors (HR=0.89, 95% CI: 0.78-1.01; p(homogeneity)=0.01). Alcohol intake is associated with an increased risk of KRAS+ and BRAF-/KRAS- tumors originating via specific molecular pathways including the traditional adenoma-carcinoma pathway but not with BRAF+ tumors originating via the serrated pathway. Therefore, limiting alcohol intake from a young age might reduce colorectal cancer originating via the traditional adenoma-carcinoma pathway.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Beroendelära0 (SwePub)303092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Substance Abuse0 (SwePub)303092 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a alcohol intake
653 a BRAF
653 a colorectal cancer
653 a KRAS
7001 a MacInnis, Robert J.4 aut
7001 a Williamson, Elizabeth J.4 aut
7001 a Hodge, Allison M.4 aut
7001 a Clendenning, Mark4 aut
7001 a Rosty, Christophe4 aut
7001 a Walters, Rhiannon4 aut
7001 a Room, Robinu Stockholms universitet,Centrum för socialvetenskaplig alkohol- och drogforskning (SoRAD),La Trobe University, Australia; The University of Melbourne, Australia4 aut0 (Swepub:su)room
7001 a Southey, Melissa C.4 aut
7001 a Jenkins, Mark A.4 aut
7001 a Milne, Roger L.4 aut
7001 a Hopper, John L.4 aut
7001 a Giles, Graham G.4 aut
7001 a Buchanan, Daniel D.4 aut
7001 a English, Dallas R.4 aut
7102 a Stockholms universitetb Centrum för socialvetenskaplig alkohol- och drogforskning (SoRAD)4 org
7730 t International Journal of Cancerd : Wileyg 140:7, s. 1485-1493q 140:7<1485-1493x 0020-7136x 1097-0215
8564 u http://minerva-access.unimelb.edu.au/bitstream/11343/292259/1/ijc.30568.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-142621
8564 8u https://doi.org/10.1002/ijc.30568

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