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Sökning: onr:"swepub:oai:DiVA.org:su-150030" > Associations of alc...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004380naa a2200577 4500
001oai:DiVA.org:su-150030
003SwePub
008171218s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1500302 URI
0247 a https://doi.org/10.1002/ijc.310492 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Jayasekara, Harindra4 aut
2451 0a Associations of alcohol intake, smoking, physical activity and obesity with survival following colorectal cancer diagnosis by stage, anatomic site and tumor molecular subtype
264 c 2017-10-04
264 1b Wiley,c 2018
338 a print2 rdacarrier
520 a The influence of lifestyle factors on survival following a diagnosis of colorectal cancer (CRC) is not well established. We examined associations between lifestyle factors measured before diagnosis and CRC survival. The Melbourne Collaborative Cohort Study collected data on alcohol intake, cigarette smoking and physical activity, and body measurements at baseline (1990-1994) and wave 2 (2003-2007). We included participants diagnosed to 31 August 2015 with incident stages I-III CRC within 10-years post exposure assessment. Information on tumor characteristics and vital status was obtained. Tumor DNA was tested for microsatellite instability (MSI) and somatic mutations in oncogenes BRAF (V600E) and KRAS. We estimated hazard ratios (HRs) for associations between lifestyle factors and overall and CRC-specific mortality using Cox regression. Of 724 eligible CRC cases, 339 died (170 from CRC) during follow-up (average 9.0 years). Exercise (non-occupational/leisure-time) was associated with higher CRC-specific survival for stage II (HR=0.25, 95% CI: 0.10-0.60) but not stages I/III disease (p for interaction=0.01), and possibly for colon and KRAS wild-type tumors. Waist circumference was inversely associated with CRC-specific survival (HR=1.25 per 10 cm increment, 95% CI: 1.08-1.44), independent of stage, anatomic site and tumor molecular status. Cigarette smoking was associated with lower overall survival, with suggestive evidence of worse survival for BRAF mutated CRC, but not with CRC-specific survival. Alcohol intake was not associated with survival. Survival did not differ by MSI status. We have identified pre-diagnostic predictors of survival following CRC that may have clinical and public health relevance.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a colorectal cancer
653 a survival
653 a alcohol intake
653 a smoking
653 a physical activity
653 a obesity
7001 a English, Dallas R.4 aut
7001 a Haydon, Andrew4 aut
7001 a Hodge, Allison M.4 aut
7001 a Lynch, Brigid M.4 aut
7001 a Rosty, Christophe4 aut
7001 a Williamson, Elizabeth J.4 aut
7001 a Clendenning, Mark4 aut
7001 a Southey, Melissa C.4 aut
7001 a Jenkins, Mark A.4 aut
7001 a Room, Robinu Stockholms universitet,Centrum för socialvetenskaplig alkohol- och drogforskning (SoRAD),La Trobe University, Australia; The University of Melbourne, Australia4 aut0 (Swepub:su)room
7001 a Hopper, John L.4 aut
7001 a Milne, Roger L.4 aut
7001 a Buchanan, Daniel D.4 aut
7001 a Giles, Graham G.4 aut
7001 a MacInnis, Robert J.4 aut
7102 a Stockholms universitetb Centrum för socialvetenskaplig alkohol- och drogforskning (SoRAD)4 org
7730 t International Journal of Cancerd : Wileyg 142:2, s. 238-250q 142:2<238-250x 0020-7136x 1097-0215
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.31049
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-150030
8564 8u https://doi.org/10.1002/ijc.31049

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