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Sökning: onr:"swepub:oai:DiVA.org:su-79795" > The interface of pr...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004474naa a2200793 4500
001oai:DiVA.org:su-79795
003SwePub
008120911s2012 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-797952 URI
0247 a https://doi.org/10.1002/pro.20712 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Liberles, David A.4 aut
2451 0a The interface of protein structure, protein biophysics, and molecular evolution
264 c 2012-04-23
264 1b Wiley,c 2012
338 a electronic2 rdacarrier
520 a The interface of protein structural biology, protein biophysics, molecular evolution, and molecular population genetics forms the foundations for a mechanistic understanding of many aspects of protein biochemistry. Current efforts in interdisciplinary protein modeling are in their infancy and the state-of-the art of such models is described. Beyond the relationship between amino acid substitution and static protein structure, protein function, and corresponding organismal fitness, other considerations are also discussed. More complex mutational processes such as insertion and deletion and domain rearrangements and even circular permutations should be evaluated. The role of intrinsically disordered proteins is still controversial, but may be increasingly important to consider. Protein geometry and protein dynamics as a deviation from static considerations of protein structure are also important. Protein expression level is known to be a major determinant of evolutionary rate and several considerations including selection at the mRNA level and the role of interaction specificity are discussed. Lastly, the relationship between modeling and needed high-throughput experimental data as well as experimental examination of protein evolution using ancestral sequence resurrection and in vitro biochemistry are presented, towards an aim of ultimately generating better models for biological inference and prediction.
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
653 a evolutionary modeling
653 a domain evolution
653 a sequence-structure-function relationships
653 a protein dynamics
653 a protein thermodynamics
653 a gene duplication
653 a protein expression
653 a ancestral sequence reconstruction
7001 a Teichmann, Sarah A.4 aut
7001 a Bahar, Ivet4 aut
7001 a Bastolla, Ugo4 aut
7001 a Bloom, Jesse4 aut
7001 a Bornberg-Bauer, Erich4 aut
7001 a Colwell, Lucy J.4 aut
7001 a de Koning, A. P. Jason4 aut
7001 a Dokholyan, Nikolay V.4 aut
7001 a Echave, Julian4 aut
7001 a Elofsson, Arneu Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)4 aut0 (Swepub:su)aelof
7001 a Gerloff, Dietlind L.4 aut
7001 a Goldstein, Richard A.4 aut
7001 a Grahnen, Johan A.4 aut
7001 a Holder, Mark T.4 aut
7001 a Lakner, Clemens4 aut
7001 a Lartillot, Nicholas4 aut
7001 a Lovell, Simon C.4 aut
7001 a Naylor, Gavin4 aut
7001 a Perica, Tina4 aut
7001 a Pollock, David D.4 aut
7001 a Pupko, Tal4 aut
7001 a Regan, Lynne4 aut
7001 a Roger, Andrew4 aut
7001 a Rubinstein, Nimrod4 aut
7001 a Shakhnovich, Eugene4 aut
7001 a Sjölander, Kimmen4 aut
7001 a Sunyaev, Shamil4 aut
7001 a Teufel, Ashley I.4 aut
7001 a Thorne, Jeffrey L.4 aut
7001 a Thornton, Joseph W.4 aut
7001 a Weinreich, Daniel M.4 aut
7001 a Whelan, Simon4 aut
7102 a Stockholms universitetb Institutionen för biokemi och biofysik4 org
7730 t Protein Scienced : Wileyg 21:6, s. 769-785q 21:6<769-785x 0961-8368x 1469-896X
8564 u https://su.diva-portal.org/smash/get/diva2:551573/FULLTEXT02.pdfx primaryx Raw objecty fulltext:postprint
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.2071
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-79795
8564 8u https://doi.org/10.1002/pro.2071

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