Sökning: onr:"swepub:oai:DiVA.org:umu-100946" > High-density genoty...
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000 | 05085naa a2200829 4500 | |
001 | oai:DiVA.org:umu-100946 | |
003 | SwePub | |
008 | 150316s2015 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:130660049 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1009462 URI |
024 | 7 | a https://doi.org/10.1136/annrheumdis-2013-2047492 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1306600492 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kim, Kwangwoo4 aut |
245 | 1 0 | a High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci |
264 | c 2014-02-14 | |
264 | 1 | b BMJ,c 2015 |
338 | a print2 rdacarrier | |
520 | a Objective A highly polygenic aetiology and high degree of allele-sharing between ancestries have been well elucidated in genetic studies of rheumatoid arthritis. Recently, the high-density genotyping array Immunochip for immune disease loci identified 14 new rheumatoid arthritis risk loci among individuals of European ancestry. Here, we aimed to identify new rheumatoid arthritis risk loci using Korean-specific Immunochip data. Methods We analysed Korean rheumatoid arthritis case-control samples using the Immunochip and genome-wide association studies (GWAS) array to search for new risk alleles of rheumatoid arthritis with anticitrullinated peptide antibodies. To increase power, we performed a meta-analysis of Korean data with previously published European Immunochip and GWAS data for a total sample size of 9299 Korean and 45 790 European case-control samples. Results We identified eight new rheumatoid arthritis susceptibility loci (TNFSF4, LBH, EOMES, ETS1-FLI1, COG6, RAD51B, UBASH3A and SYNGR1) that passed a genome-wide significance threshold (p<5x10(-8)), with evidence for three independent risk alleles at 1q25/TNFSF4. The risk alleles from the seven new loci except for the TNFSF4 locus (monomorphic in Koreans), together with risk alleles from previously established RA risk loci, exhibited a high correlation of effect sizes between ancestries. Further, we refined the number of single nucleotide polymorphisms (SNPs) that represent potentially causal variants through a trans-ethnic comparison of densely genotyped SNPs. Conclusions This study demonstrates the advantage of dense-mapping and trans-ancestral analysis for identification of potentially causal SNPs. In addition, our findings support the importance of T cells in the pathogenesis and the fact of frequent overlap of risk loci among diverse autoimmune diseases. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
700 | 1 | a Bang, So-Young4 aut |
700 | 1 | a Lee, Hye-Soon4 aut |
700 | 1 | a Cho, Soo-Kyung4 aut |
700 | 1 | a Choi, Chan-Bum4 aut |
700 | 1 | a Sung, Yoon-Kyoung4 aut |
700 | 1 | a Kim, Tae-Hwan4 aut |
700 | 1 | a Jun, Jae-Bum4 aut |
700 | 1 | a Yoo, Dae Hyun4 aut |
700 | 1 | a Kang, Young Mo4 aut |
700 | 1 | a Kim, Seong-Kyu4 aut |
700 | 1 | a Suh, Chang-Hee4 aut |
700 | 1 | a Shim, Seung-Cheol4 aut |
700 | 1 | a Lee, Shin-Seok4 aut |
700 | 1 | a Lee, Jisoo4 aut |
700 | 1 | a Chung, Won Tae4 aut |
700 | 1 | a Choe, Jung-Yoon4 aut |
700 | 1 | a Shin, Hyoung Doo4 aut |
700 | 1 | a Lee, Jong-Young4 aut |
700 | 1 | a Han, Bok-Ghee4 aut |
700 | 1 | a Nath, Swapan K.4 aut |
700 | 1 | a Eyre, Steve4 aut |
700 | 1 | a Bowes, John4 aut |
700 | 1 | a Pappas, Dimitrios A.4 aut |
700 | 1 | a Kremer, Joel M.4 aut |
700 | 1 | a Gonzalez-Gay, Miguel A.4 aut |
700 | 1 | a Rodriguez-Rodriguez, Luis4 aut |
700 | 1 | a Ärlestig, Lisbethu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)litarg99 |
700 | 1 | a Okada, Yukinori4 aut |
700 | 1 | a Diogo, Dorothee4 aut |
700 | 1 | a Liao, Katherine P.u Karolinska Institutet4 aut |
700 | 1 | a Karlson, Elizabeth W.4 aut |
700 | 1 | a Raychaudhuri, Soumya4 aut |
700 | 1 | a Rantapää-Dahlqvist, Solbrittu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sora0001 |
700 | 1 | a Martin, Javier4 aut |
700 | 1 | a Klareskog, Larsu Karolinska Institutet4 aut |
700 | 1 | a Padyukov, Leonid4 aut |
700 | 1 | a Gregersen, Peter K.4 aut |
700 | 1 | a Worthington, Jane4 aut |
700 | 1 | a Greenberg, Jeffrey D.4 aut |
700 | 1 | a Plenge, Robert M.4 aut |
700 | 1 | a Bae, Sang-Cheol4 aut |
710 | 2 | a Umeå universitetb Reumatologi4 org |
773 | 0 | t Annals of the Rheumatic Diseasesd : BMJg 74:3q 74:3x 0003-4967x 1468-2060 |
856 | 4 | u https://europepmc.org/articles/pmc4467986?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100946 |
856 | 4 8 | u https://doi.org/10.1136/annrheumdis-2013-204749 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130660049 |
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