Vitamin D-Associated Genetic Variation and Risk of Breast Cancer in the Breast and Prostate Cancer Cohort Consortium (BPC3)

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Fältnamn	Indikatorer	Metadata
000		04331naa a2200757 4500
001		oai:DiVA.org:umu-102376
003		SwePub
008		150423s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:130963189
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1023762 URI
024	7	a https://doi.org/10.1158/1055-9965.EPI-14-11272 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1309631892 URI
040		a (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Mondul, Alison M.4 aut
245	1 0	a Vitamin D-Associated Genetic Variation and Risk of Breast Cancer in the Breast and Prostate Cancer Cohort Consortium (BPC3)
264	1	c 2015
338		a print2 rdacarrier
520		a Background: Two recent genome-wide association studies (GWAS) identified SNPs in or near four genes related to circulating 25-hydroxyvitamin D [25(OH) D] concentration. To examine the hypothesized inverse relationship between vitamin D status and breast cancer, we studied the associations between SNPs in these genes and breast cancer risk in a large pooled study of 9,456 cases and 10,816 controls from six cohorts. Methods: SNP markers localized to each of four genes (GC, CYP24A1, CYP2R1, and DHCR7) previously associated with 25 (OH) D were genotyped and examined both individually and as a 4-SNP polygenic score. Logistic regression was used to estimate the associations between the genetic variants and risk of breast cancer. Results: We found no association between any of the four SNPs or their polygenic score and breast cancer risk. Conclusions: Our findings do not support an association between vitamin D status, as reflected by 25(OH) D-related genotypes, and breast cancer risk. Impact: These findings may contribute to future meta-analyses and scientific review articles, and provide new data about the association between vitamin D-related genes and breast cancer.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
700	1	a Shui, Irene M.4 aut
700	1	a Yu, Kai4 aut
700	1	a Weinstein, Stephanie J.4 aut
700	1	a Tsilidis, Konstantinos K.4 aut
700	1	a Joshi, Amit D.4 aut
700	1	a Agudo, Antonio4 aut
700	1	a Berg, Christine D.4 aut
700	1	a Black, Amanda4 aut
700	1	a Buring, Julie E.4 aut
700	1	a Chasman, Daniel I.4 aut
700	1	a Gaudet, Mia M.4 aut
700	1	a Haiman, Christopher4 aut
700	1	a Hankinson, Susan E.4 aut
700	1	a Henderson, Brian E.4 aut
700	1	a Hoover, Robert N.4 aut
700	1	a Hunter, David J.4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Kuehn, Tilman4 aut
700	1	a Kvaskoff, Marina4 aut
700	1	a Le Marchand, Loic4 aut
700	1	a Lindstroem, Sara4 aut
700	1	a McCullough, Marjorie L.4 aut
700	1	a Overvad, Kim4 aut
700	1	a Peeters, Petra H.4 aut
700	1	a Riboli, Elio4 aut
700	1	a Ridker, Paul M.4 aut
700	1	a Stram, Daniel O.4 aut
700	1	a Sund, Malinu Umeå universitet,Kirurgi4 aut0 (Swepub:umu)masu0021
700	1	a Trichopoulos, Dimitrios4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Weiderpass, Elisabeteu Karolinska Institutet4 aut
700	1	a Willett, Walter4 aut
700	1	a Kraft, Peter4 aut
700	1	a Ziegler, Regina G.4 aut
700	1	a Albanes, Demetrius4 aut
710	2	a Umeå universitetb Kirurgi4 org
773	0	t Cancer Epidemiology, Biomarkers and Preventiong 24:3, s. 627-630q 24:3<627-630x 1055-9965x 1538-7755
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102376
856	4 8	u https://doi.org/10.1158/1055-9965.EPI-14-1127
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:130963189

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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