SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:umu-150859"
 

Sökning: onr:"swepub:oai:DiVA.org:umu-150859" > Germline variants i...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007344naa a2200697 4500
001oai:DiVA.org:umu-150859
003SwePub
008180907s2018 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-360483
009oai:prod.swepub.kib.ki.se:138690424
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1508592 URI
0247 a https://doi.org/10.1038/s41391-017-0029-22 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3604832 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1386904242 URI
040 a (SwePub)umud (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a FitzGerald, L. M.u Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia;Univ Tasmania, Menzies Inst Med Res, Canc Genet & Immunol, Hobart, Tas 7001, Australia4 aut
2451 0a Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality :b an analysis of 12,082 prostate cancer cases
264 c 2018-01-03
264 1b Nature Publishing Group,c 2018
338 a electronic2 rdacarrier
520 a Background Prostate cancer (PCa) is a leading cause of mortality and genetic factors can influence tumour aggressiveness. Several germline variants have been associated with PCa-specific mortality (PCSM), but further replication evidence is needed. Methods Twenty-two previously identified PCSM-associated genetic variants were genotyped in seven PCa cohorts (12,082 patients; 1544 PCa deaths). For each cohort, Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals for risk of PCSM associated with each variant. Data were then combined using a meta-analysis approach. Results Fifteen SNPs were associated with PCSM in at least one of the seven cohorts. In the meta-analysis, after adjustment for clinicopathological factors, variants in the MGMT (rs2308327; HR 0.90; p-value = 3.5 x 10(-2)) and IL4 (rs2070874; HR 1.22; p-value = 1.1 x 10(-3)) genes were confirmed to be associated with risk of PCSM. In analyses limited to men diagnosed with local or regional stage disease, a variant in AKT1, rs2494750, was also confirmed to be associated with PCSM risk (HR 0.81; p-value = 3.6 x 10(-2)). Conclusions This meta-analysis confirms the association of three genetic variants with risk of PCSM, providing further evidence that genetic background plays a role in PCa-specific survival. While these variants alone are not sufficient as prognostic biomarkers, these results may provide insights into the biological pathways modulating tumour aggressiveness.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Zhao, S.u NIEHS, Biostat & Computat Biol Branch, Res Triangle Pk, NC 27709 USA4 aut
7001 a Leonardson, A.u Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA4 aut
7001 a Geybels, M. S.u Maastricht Univ, Med Ctr, GROW Sch Oncol & Dev Biol, Dept Epidemiol, NL-6211 LK Maastricht, Netherlands;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA4 aut
7001 a Kolb, S.u Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA4 aut
7001 a Lin, D. W.u Univ Washington, Sch Med, Dept Urol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA4 aut
7001 a Wright, J. L.u Univ Washington, Sch Med, Dept Urol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA4 aut
7001 a Eeles, R.u Royal Marsden Natl Hlth Serv Fdn Trust, London, England;Royal Marsden Natl Hlth Serv Fdn Trust, Sutton SW3 6JJ, Surrey, England;Inst Canc Res, Sutton SM2 5NG, Surrey, England4 aut
7001 a Kote-Jarai, Z.u Inst Canc Res, Sutton SM2 5NG, Surrey, England4 aut
7001 a Govindasami, K.u Inst Canc Res, Sutton SM2 5NG, Surrey, England4 aut
7001 a Giles, G. G.u Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Carlton, Vic 3053, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia4 aut
7001 a Southey, M. C.u Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Parkville, Vic 3010, Australia4 aut
7001 a Schleutker, J.u Turku Univ Hosp, Dept Med Genet, Tuch Microbiol & Genet, Turku 20520, Finland;Univ Turku, Dept Med Biochem & Genet, Inst Biomed, Turku 20014, Finland4 aut
7001 a Tammela, T. L.u Tampere Univ Hosp, Dept Urol, Tampere 33521, Finland;Univ Tampere, Prostate Canc Res Ctr, Sch Med, Tampere 33100, Finland4 aut
7001 a Sipeky, C.u Univ Turku, Dept Med Biochem & Genet, Inst Biomed, Turku 20014, Finland4 aut
7001 a Penney, K. L.u Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA;Brigham & Womens Hosp, Dept Med, Charming Div Network Med, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA4 aut
7001 a Stampfer, M. J.u Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA;Brigham & Womens Hosp, Dept Med, Charming Div Network Med, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA4 aut
7001 a Gronberg, H.u Karolinska Institutet4 aut
7001 a Wiklund, F.u Karolinska Institutet4 aut
7001 a Stattin, P.u Uppsala universitet,Umeå universitet,Urologi och andrologi,Urologkirurgi,Umea Univ, Dept Surg & Perioperat Sci, S-90187 Umea, Sweden4 aut0 (Swepub:uu)parst892
7001 a Hugosson, J.u Univ Goteborgs, Inst Clin Sci, Dept Urol, S-40530 Goteborgs, Sweden4 aut
7001 a Karyadi, D. M.u NHGRI, NIH, Bethesda, MD 20854 USA4 aut
7001 a Ostrander, E. A.u NHGRI, NIH, Bethesda, MD 20854 USA4 aut
7001 a Feng, Z.u MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA4 aut
7001 a Stanford, J. L.u Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA4 aut
7102 a Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia;Univ Tasmania, Menzies Inst Med Res, Canc Genet & Immunol, Hobart, Tas 7001, Australiab NIEHS, Biostat & Computat Biol Branch, Res Triangle Pk, NC 27709 USA4 org
7730 t Prostate Cancer and Prostatic Diseasesd : Nature Publishing Groupg 21:2, s. 228-237q 21:2<228-237x 1365-7852x 1476-5608
8564 u https://doi.org/10.1038/s41391-017-0029-2y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1246511/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/s41391-017-0029-2.pdf
8564 u https://uu.diva-portal.org/smash/get/diva2:1248557/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150859
8564 8u https://doi.org/10.1038/s41391-017-0029-2
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-360483
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:138690424

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy