Sökning: onr:"swepub:oai:DiVA.org:umu-155826" > Identification of S...
Fältnamn | Indikatorer | Metadata |
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000 | 04154naa a2200529 4500 | |
001 | oai:DiVA.org:umu-155826 | |
003 | SwePub | |
008 | 190128s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1558262 URI |
024 | 7 | a https://doi.org/10.1038/s41598-018-37449-y2 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Espín-Pérez, Almudena4 aut |
245 | 1 0 | a Identification of Sex-Specific Transcriptome Responses to Polychlorinated Biphenyls (PCBs) |
264 | c 2019-01-24 | |
264 | 1 | b Nature Publishing Group,c 2019 |
338 | a electronic2 rdacarrier | |
520 | a PCBs are classified as xenoestrogens and carcinogens and their health risks may be sex-specific. To identify potential sex-specific responses to PCB-exposure we established gene expression profiles in a population study subdivided into females and males. Gene expression profiles were determined in a study population consisting of 512 subjects from the EnviroGenomarkers project, 217 subjects who developed lymphoma and 295 controls were selected in later life. We ran linear mixed models in order to find associations between gene expression and exposure to PCBs, while correcting for confounders, in particular distribution of white blood cells (WBC), as well as random effects. The analysis was subdivided according to sex and development of lymphoma in later life. The changes in gene expression as a result of exposure to the six studied PCB congeners were sex- and WBC type specific. The relatively large number of genes that are significantly associated with PCB-exposure in the female subpopulation already indicates different biological response mechanisms to PCBs between the two sexes. The interaction analysis between different PCBs and WBCs provides only a small overlap between sexes. In males, cancer-related pathways and in females immune system-related pathways are identified in association with PCBs and WBCs. Future lymphoma cases and controls for both sexes show different responses to the interaction of PCBs with WBCs, suggesting a role of the immune system in PCB-related cancer development. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a epidemiologi | |
653 | a Epidemiology | |
700 | 1 | a Hebels, Dennie G. A. J.4 aut |
700 | 1 | a Kiviranta, Hannu4 aut |
700 | 1 | a Rantakokko, Panu4 aut |
700 | 1 | a Georgiadis, Panagiotis4 aut |
700 | 1 | a Botsivali, Maria4 aut |
700 | 1 | a Bergdahl, Ingvaru Umeå universitet,Yrkes- och miljömedicin,Enheten för biobanksforskning4 aut0 (Swepub:umu)inbe0001 |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Späth, Florentin,d 1980-u Umeå universitet,Enheten för biobanksforskning,Yrkes- och miljömedicin4 aut0 (Swepub:umu)flsp0001 |
700 | 1 | a Johansson, Andersu Umeå universitet,Enheten för biobanksforskning,Yrkes- och miljömedicin,Aa-gruppen4 aut0 (Swepub:umu)anjo0002 |
700 | 1 | a Chadeau-Hyam, Marc4 aut |
700 | 1 | a Kyrtopoulos, Soterios A4 aut |
700 | 1 | a Kleinjans, Jos C. S.4 aut |
700 | 1 | a de Kok, Theo M. C. M.4 aut |
710 | 2 | a Umeå universitetb Yrkes- och miljömedicin4 org |
773 | 0 | t Scientific Reportsd : Nature Publishing Groupg 9q 9x 2045-2322 |
856 | 4 | u https://doi.org/10.1038/s41598-018-37449-yy Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1283312/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.nature.com/articles/s41598-018-37449-y.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-155826 |
856 | 4 8 | u https://doi.org/10.1038/s41598-018-37449-y |
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